Microfluidic Control System for Lab Automation
Standard laboratory perform manual bioanalysis with mL range sample volumes, expensive equipment, and specialized laboratory technicians. With microfabrication, microfluidics was developed for lab automation with nano to picoliter volume scale on the wafer scale. This microfluidic technique enable inexpensive, portable and automated bioinstruments. The sample processing steps, which involve sample metering, transporting, mixing and storing actions can be time-consuming, labor-intensive, and should be automated for a fully autonomous platform. In order to develop a fully autonomous, miniaturized bio-analysis platform, a microfluidic sample processor with sufficient programmability for a wide range of sample processing operations is essential. By developing microfluidic control system, we can achive an automated, miniaturized and programmable microfluidic platform.
Biomedical Devices for Personalized Medicine
Over two million cases of serious, adverse drug reactions are reported annually in the United States, and 100 thousands people die each year from incorrect drug dosage. A new method for prescribing drugs is necessary to prevent these problems. Personalized medicine uses information from a patient's genetic/proteomic profile to determine appropriate dosage. For example, Plavix well known anti-platelet drug showed heterogeneous platelet aggregation response from same dosage. Overdose of plavix have serious breeding when patient have wound, lower dose can create the blood clot to block the blood stream. By genetic and proteomic analysis, doctor can prescribe exact amount medicine to patients. Current measurement devices are complicated process and need intensive sample preparation steps. Our lab actively seek new type of biomedical tools to know the drug response from a single drop of samples precisely and rapidly.
Tissue engineering and high-throughput cell screening tools
Autologous bone transplantation is a common techique to help the bone regeneration. However, it is painful extraction step, lack of structural integrity and limited volume. Tissue engineering have been developed and tried to provide these transplantation problems with engineered bone tissue. The common process to create the bone graft is to use 3D scaffold to geneate the artificial bone. By optimizing the bioreactor for the creation of bone graft, all the fabrication process can be shorten. Using microfluidic micro-actuator, we are able to create more precise and robust dynamic cell culture system. With this device, We will be able to achieve the minimal contamination, high throughput, precise control of mechanical stimulation and real-time monitoring and cell screening.