Microfluidic Control System for Lab Automation

Standard laboratory perform manual bioanalysis with mL range sample volumes, expensive equipment, and specialized laboratory technicians. With microfabrication, microfluidics was developed for lab automation with nano to picoliter volume scale on the wafer scale. This microfluidic technique enables inexpensive, portable and automated bioinstruments. The sample processing steps, which involve sample metering, transporting, mixing and storing actions can be time-consuming, labor-intensive, and should be automated for a fully autonomous platform. In order to develop a fully autonomous, miniaturized bio-analysis platform, a microfluidic sample processor with sufficient programmability for a wide range of sample processing operations is essential. Using both pneumatic actuations and digital microfluidic systems, we are developing an automated, miniaturized and programmable microfluidic platform.

Biomedical Devices for Personalized Medicine

Over two million cases of serious, adverse drug reactions are reported annually in the United States, and 100 thousands people die each year from incorrect drug dosage. A new method for prescribing drugs is necessary to prevent these problems. Personalized medicine uses information from a patient's genetic/proteomic profile to determine appropriate dosage. By genetic and proteomic analysis, doctor can prescribe exact amount medicine to patients. Current measurement devices are complicated process and need intensive sample preparation steps. Our lab actively seek new type of biomedical tools to know the drug response from a single drop of samples precisely and rapidly.

Organ-on-a-chip: Microphysiological biosystems

Both disease mechanism studies and drug tests generally require whole animals or freshly dissected body parts. Such experiments are costly, and can raise ethical issues. In vitro microphysiological biosystems could reduce these issues and provide alternative models. The systems are particularly well-suited for multi-variable bioassays, offering systematic control of all experimental variables. In addition, the biomimetic system can be replicated to create a high-throughput experimental platform for hundreds of experiments simultaneously. With these advantages, the biomimetic system reduces discovery time and the consumption of expensive reagents and cells, and allows the integration of detection assays directly in the microsystems.