Guigen Li, Ph.D.
Recent Honors
Chancellor Distinguished Research Award, Texas Tech University, 2004-2005.
Distinguished Oversea Scholar, Chinese Academy of Sciences, 2004.
Tokai Branch Lectureship, the Synthetic Organic Chemistry Society of Japan, 2005.
2004-05 Siemens Westinghouse Competition Mentor, Siemens Foundation, USA, 2004.
Publication List
1. Simultaneous Measurement of Primary and Secondary Kinetic Deuterium Isotope Effects by Natural-Abundance 2H-NMR (II). Zhang, B.-L.; Li, G.; Gao, Z.-H Chem. J. Chinese Univ., 1988, 9, 808-13.
2. Simultaneous Measurement of Primary and Secondary Kinetic Deuterium Isotope Effects by Natural-Abundance 2H-NMR (III)---Application to the Hydrolysis of Some Grinard Reagents. Zhang, B.-L.; Li, G.; Gao, Z.-H. Chem. J. Chinese Univ., 1989, 10, 667-9.
3. Determination of Kinetic Isotope Effects by Natural Abundance 2H-NMR. Li, G. Huaxue Tongbao (Chemistry), 1988, 8, 25-30.
4. Topographical Considerations in Computerized Peptide Design. Hruby, V. J.; Misicka, A.; Nicolas, E.; Russell, K. C.; Li, G.; Nikiforovich, G.; Prakash, O; Jiao, J.; Kover, K. Peptides: Biology and Chemistry, Proc. of 2nd Chinese Peptide Symp. Y. Du, J. P. Tam and Y.-S. Zhang eds., ESCOM Sci. Publ., Leiden, 1993, 207-210.
5. Diastereospecific Tandem Michael-Like Addition/Electrophilic Bromination: A One-Pot Asymmetric Synthesis of Precursors of Unusual Amino Acids. Li, G.; Jarosinski, M. A.; Hruby, V. J. Tetrahedron Lett., 1993, 34, 2561-64.
6. Asymmetric Synthesis of Unusual Amino Acids: An Enantioselective Synthesis of the Four Isomers of D- and L-O-Methyl-2', b-Dimethyltyrosines. Li, G.; Russell, K. C.; Jarosinski, M. A.; Hruby, V. J. Tetrahedron Lett., 1993, 34, 2565-68.
7. A New Method for the Synthesis of the Optically Pure Precursors to b-Methyl Derivatives of Histidine, Tryptophan, Tyrosine and Phenylalanine. Li, G.; Boteju, L.W.; Petal, D.; Hruby, V. J. Peptides: Chemistry and Biology, 1994, 181-183, Hodges, R. S.; Smith, J. A. eds., ESCOM Publishers, Leiden.
8. An Efficient Procedure for the Demethylation of Aryl-Methyl Ethers in Optically Pure Amino Acids. Li, G.; Patel, D.; Hruby, V. J. Tetrahedron Lett., 1993, 34, 5393-96.
9. Asymmetric Synthesis of The (2R, 3S) and (2S, 3R) Precursors of b-Methyl-His, -Phe and-Tyr. Li, G.; Patel, D; Hruby, V. J. Tetrahedron Asymmetry, 1993, 4, 2315-18.
10. 1, 2- cis- Asymmetric Induction and its Application to the Asymmetric Synthesis of Precursors to Unusual Amino Acids. Li, G.; Patel, D; Hruby, V. J. Tetrahedron Lett., 1994, 35, 2301-2305.
11. The New Strategy for the Total Synthesis of Four Individual Isomers of b-Branched Amino Acids. Lung, F.-D. T.; Li, G.; Hruby, V. J. Synth Commun., 1995, 25, 57-61.
12. Exploration for Large-scale Stereoselective Synthesis of Unusual Amino Acids by Using 4-Phenyl-Oxazolidin-2-one as a New Chiral Resolution Reagent. Li, G.; Patel, D.; Hruby, V. J. J. Chem. Soc., Perkin Trans.1, 1994, 21, 3057-3059.
13. Effects of Modification of the Residue in the 1 and 3 Position of Dynophin A (1-11)-NH2 on the Potency and Selectivity for Kappa Opioid Receptors. Lung, F.-D. T.; Meyer, J.-P.; Li, G.; Lou, B.-S.; Stropova, D.; Davies, P.; Porecca, F.; Yamamura, H. I.; Hruby, V. J. J. Med. Chem., 1995, 38, 585-586.
14. Design, Synthesis and Conformation in Chi Space for the Development of Selective Peptides for Types and Subtypes of Receptors. Hruby, V. J.; Li, G.; Qian, X.; Haskell-Luevano, C.; Lung, F.-D.; Kover, K.; Misicka, A.; Yamamura, H. I.; Porreca, F.; Davies, T. F. Peptides 1994., H. L. S. Maia, ed., ESCOM Sci. Publ., 1995, pp 62-64.
15. Asymmetric Amino Acids Substitution at Tyr10 Position of Glucagon Leads to Greater Binding Differences. Azizh, B. Y.; Trivedi, D.; Sturm, N. S.; David, C.; Hutzler, A. M.; Van Tine, B. A.; Dandrea, D.; Li, G.; Hruby, V. J. Peptides 1994, H. L. S. Maia, ed., ESCOM Sci. Publ., 1995, pp 621-622.
18. Structure-Activity Relationship and Synthetic Studies for Biphalin-1,1’-Stereochemical and Truncation Modifications. Li, G.; Haq, W.; De Leon, I. A.; Xiang, L.; Hughes, R.; Lou, B.; Davis, P.; Porreca, F.; Davis, T.; Romanowski, M.; Zhu, X.; Misicka, A.; Lipkowski, A.; Yamamura, H. I.; O'Brien, D. F.; Hruby, V. J. Peptides: Chemistry, Structure and Biology, P. T. P. Kaumaya and R. S. Hodges, Eds. Mayflower Sci. Ltd., Kingswingford, England, 1996, pp 699-700.
19. A Systematic Investigation of Factors that Enchance Penetration of the Blood Brain Barrier. Hruby, V. J.; Davis, T. P.; Polt, R.; Bartosz-Bechomski, H.; Misicka, A.; Lipkowski, A.; Sharma, S. D.; Li, G.; Bonner, G.; Meyer, J.-P.; Qian, X.; Romanowski, M.; Yamamura, H. I.; Porreca, F.; O'Brien, D. F. Peptides: Chemistry, Structure and Biology, P. T. P. Kaumaya and R. S. Hodges, Eds. Mayflower Sci. Ltd., Kingswingford, England, 1996, pp 154-156.
20. NMR Investigation of Asymmetric Conjugate Addition Reaction Using Chiral 4-Phenyloxazolidinone as a Mechanistic Probe. Lou, B.-S.; Li, G.; Lung, F.-D.; Hruby, V. J. J. Org. Chem., 1995, 60, 5509-14.
21. Design and Synthesis of Peptide Ligands with Unique Biochemical and Biological Properties at Opioid Receptors that Cross the Blood Brain Barrier. Hruby, V. J.; Davis, T. P.; Polt, R.; O'Brien, D.; Yamamura, H. I.; Bartosz, H.; Szabo, L.; Gillespie, T. J.; Misicka, A.; Lipkowski, A.; Qian, X.; Li, G.; Patel, D.; Bonner, G. Analgesia, 1995, 1, 469-472.
22. Effects of Modifications of Residues in Position 3 of Dynorphin A(1-11)-NH2 on k Receptor Selectivity and Potency. Lung, F.-D.; Meyer, J.-P.; Lou, B.-S.; Xiang, L.; Li, G.; Davies, P.; De Leon, I. A.; Yamamura, H. I.; Porreca, F.; Hruby, V. J. J. Med. Chem., 1996, 39, 2456-2460.
23. Topographical Amino Acid Substitution in Position 10 of Glucagon Leads to Antagonist/Partial Agonist with Greater Binding Differences, Azizh, B. Y.; Shenderovich, M. D.; Trivedi, D.; Li, G.; Sturm, N. S.; Hruby, V. J. J. Med. Chem., 1996, 39, 2449-2455.
24. Catalytic Asymmetric Aminohydroxylation (AA) of Olefins. Li, G.; Chang, H.-T.; Sharpless, K. B. Angew. Chem. Int. Ed. Engl., 1996, 35, 451-454.
25. A Large-scale Taxol Side-chain Synthesis by Catalytic Aminohydroxylation. Li, G.; Sharpless, K. B. Acta Chem. Scand., 1996, 50, 649-651.
26. N-Halocarbamate Salts Lead to More Efficient Catalytic Asymmetric Aminohydroxylation. Li, G.; Angert, H. H.; Sharpless, K. B. Angew. Chem. Int. Ed. Engl. 1996, 35, 2813-2817.
27. Design of Peptide and Peptidomimetics in Chi Space. Hruby, V. J.; Li, G.; Haskell-Luevano, C.; Shanderovich, M. Peptide Science-Biopolymers, 219-266, 43, 1997.
28. 4, 4'-Stereochemical Modifications and SAR study for Biphalin, a Highly Potent Opioid Receptor Active Peptide. Li, G.; Haq, W.; Xiang, L.; Lou, B.-S.; Hughes, R.; De Leon, I. A.; Davis, P.; Gillespie, T. J.; Romanowski, M.; Zhu, X.-Y.; Misicka, A.; Lipkowski, A. W.; Porreca, F.; Davis, T. P.; Yamamura, H. I.; O'Brien, D. F.; Hruby, V. J. Bioorg. Med. Chem. Lett., 1998, 8, 555-560.
(Patents 29-32 )
29. Two Steps Synthesis of D- and L-a-Amino Acids and a-Amino Aldehydes. Sharpless, K. B.; Li, G. US Patent Number 6,509,506, January 21, 2003.
30. Catalytic Asymmetric Aminohydroxylation of Olefins with Carbamates in Organic-Aqueous Solvents. Sharpless, K. B.; Li, G. US Patent Number 5,767,304, June 16, 1998.
31. Catalytic Asymmetric Aminohydroxylation of Olefins with Sulfonamides. Sharpless, K. B.; Li, G.; Chang, H.-T. US Patent Number 5,859,281, January 12, 1999.
32. Catalytic Asymmetric Aminohydroxylation of Olefins with n-Halo Carboxamides. Sharpless, K. B.; Nicolaou, K. C.; Li, G.; Guy, R US Patent Number 5,994,583, November 30, 1999.
(Publications as the Principal Investigator from Texas Tech since September 1997)
33. New Synthesis of Evans Chiral Oxazolidinones by Using Sharpless AA Reaction. Li, G.; Lenington, R.; Willis, S.; Kim, S. H. J. Chem. Soc., Perkin Trans. 1 1998, 1753-1754.
34. A New Stereospecific Synthesis of Unusual (Z)-b-Branched Baylis-Hillman Adducts. Li, G.; Wei, H.-X.; Willis, S. Tetrahedron Lett. 1998, 39, 4607-4610.
35. Lewis Acid-Promoted Carbonyl Addition of Lithium (a-Carbalkoxyvinyl)cuprates to Aldehydes Provides a Novel Asymmetric Synthesis of b,b-Disubstituted a-(Hydroxyalkyl)acrylates. Wei, H.-X.; Willis, S.; Li, G. Tetrahedron Lett. 1998, 39, 8203-8206.
36. Copper-Mediated Carbon-Carbon Coupling for the Synthesis of b,b-Disubstituted and (Z)-b-Monosubstituted Baylis-Hillman Adducts. Wei, H.-X.; Willis, S.; Li, G. Synth. Commun. 1999, 29, 2959-2966.
37. A Novel Asymmetric C-C Bond Formation Process Promoted by Et2AlCl and Its Application to the Stereoselective Synthesis of Unusual b-Branched Baylis-Hillman Adducts. Li, G.; Wei, H.-X.; Whittlesey, B.; Batrice, N. N. J. Org. Chem. 1999, 64, 1061-1064.
38. A Mild Procedure for the Stereospecific Transformation of trans Cinnamic Acid Derivatives to cis b-Bromostyrenes. Kim, S. H.; Wei, H.-X.; Willis, S.; Li, G. Synth. Commun. 1999, 29, 4179-4185.
39. Ytterbium (III) Triflate-Catalyzed Asymmetric Nucleophilic Addition of Functionalized Lithium (a-carbalkoxyvinyl)cuprates to Chiral p-Toluenesulfinimines (Thiooxime S-oxides). Li, G.; Wei, H.-X.; Hook, J. D. Tetrahedron Lett. 1999, 40, 4611-4614.
40. Asymmetric Synthesis of b-Monosubstituted and b,b-Disubstituted a-(Aminoalkyl)acrylates via Anionic Additions of (a-Carbalkoxyvinyl)cuprates to Thiooxime S-Oxides. Wei, H.-X.; Hook, J. D.; Fitzgerald, K. A.; Li, G. Asymmetric Synthesis of b-Monosubstituted and b,b-Disubstituted a-(Aminoalkyl)acrylates via Anionic Additions of (a-Carbalkoxyvinyl)cuprates to Thiooxime S-Oxides. Tetrahedron: Asymmetry 1999, 10, 661-665.
41. Transition Metal-Catalyzed Regioselective and Stereoselective Aminochlorination of Cinnamic Esters. Li, G.; Wei, H.-X.; Kim, S.-H.; Margret, M. Org. Lett. 1999, 1, 395-397.
42. Asymmetric Synthesis of Free Unusual b-Amio Acids via Nucleophilic Additions of (a-Carbalkoxyvinyl)cuprates to Thiooxime S-oxides Following by New Deprotection Conditions.
Li, G.; Wei, H.-X.; Kim, S.-H; Hook, J. D.; Fitzgerald, K. A. Peptides for the New Millennium: Proceedings of the 16th American Peptide Symposium Fields, G. B.; Tam, J. B.; Barany, G. Kluwer Academic Publ., 2000, 68-69.
43. TiCl4-Mediated Baylis-Hillman and Aldol Reactions without the Direct Use of a Lewis Base. Li, G.; Wei, H.-X.; Gao, J.; Caputo, T. D. Tetrahedron Lett. 2000, 41, 1-5.
44. Highly Efficient Deprotection of N-p-Toluenesulfinyl Group of Unusual Baylis-Hillman Adducts by Using Amberlite IR-120 (Plus) Ion-Exchange Resin. Li, G.; Kim, S. H.; Wei, H.-X. Tetrahedron 2000, 56, 719-723.
45. New C=C Bond Formation via a Non-Stoichiometric Titanium (VI) Halide-Mediated Vicinal Difuctionalization of a,b-Unsaturated Acyclic Ketones. Li, G.; Gao, J.; Wei, H.-X.; Enright, M. Org. Lett. 2000, 2, 617-620.
46. Highly Regio and Stereoselective a-Hydroxyalkylation/b-Chlorination of a,b-Acetylenic Ketones---an Efficient Approach to b-Halogenated Baylis-Hillman Adducts. Wei, H.-X.; Caputo, T. D.; Purkiss, P. W.; Li, G. Tetrahedron 2000, 56, 2397-2401.
47. a,b-Differentiated Diamination of Cinnamic Esters Using N,N-Dichloro-o-nitrobenzenesulfonamide and Acetonitrile as the Nitrogen Sources. Li, G.; Kim, S. H.; Wei, H.-X. Tetrahedron Lett. 2000, 41, 8699-8701.
48. Copper-Catalyzed Aminohalogenation Using 2-NsNCl2/2-NsNHNa Combination as the Nitrogen and Halogen Sources for the Synthesis of anti Alkyl 3-Chloro-2-(o-Nitrobenzenesulfonamido)-3-Arylpropionates. Li, G.; Wei, H.-X.; Kim, S. H. Org. Lett. 2000, 2. 2249-2252.
49. Halo Aldol Reaction of a,b-Unsaturated Ketones and Aldehydes Mediated by Titanium Tetrachloride without the Direct Use of a Lewis Base. Li, G.; Wei, H.-X.; Karur, S. Molecules 2000, 5, 1408-1416.
50. Li, G.; Hook, J. D.; Wei, H.-X. Further Functionalisation of Baylis-Hillman Adducts in Stereoselective Fashions. in "Recent Research Developments in Organic & Bioorganic Chemistry", Transworld Research Network, 2001, 4, pp 49-61.
51. The Asymmetric Catalytic Aldol Reaction of Allenolates with Aldehydes using N-Fluoroacetyl Oxazaborolidine as the Catalyst. Li, G.; Wei, H.-X.; Phelps, B. S.; Purkiss, D. W.; Kim, S. H. Org. Lett. 2001, 3, 823-826.
52. The First Transition Metal-Ligand Complex-Catalyzed Regioselective and Stereoselective Aminohalogenation of Cinnamic Esters. Wei, H.-X.; Kim, S. –H.; Li, G.; Tetrahedron 2001, 57, 3869-3973.
53. Unexpected Cu-Catalytic Aminohalogenation Reaction of Olefins with N-Halogeno-N-Metallo-Sulfonamide as the Nitrogen/Halogen Source. Li, G.; Wei, H.-X.; Kim, S. H.; Tetrahedron 2001, 57, 8407-8411.
54. A Novel Three-Component Olefinic Reaction. Li, G.; Wei, H.-X.; Kim, S.-H.; Carducci, M. D. Angew. Chem. Int. Ed., 2001, 40, 4277-4280.
55. Substoichiometric TiCl4-Mediated Vicinal Difunctionalization of a,b-Acetylenic Ketones for the Synthesis of b-Halo Baylis-Hillman Olefins. Wei, H.-X.;. Gao, J.; Li, G. Li, G. Tetrahedron Lett. 2001, 42, 9119-9122.
56. Z/E Stereoselective Synthesis of b-Bromo Baylis-Hillman Ketones via A One-pot Three-component X-C/C-C Formation Reaction. Wei, H.-X.; Gao, J.; Johnson, J.; Li, G. Synth. Commun. 2002, 32, 1765-1773.
57. Three-Component Halogeno Aldol Condensation of a,b-Alkyl Thioacrylates with Aldehydes Mediated by Titanium (IV) Halide. Kim, S.-H.; Wei, H.-X.; Gao, J.; Li, G. Molecules 2002, 89-95.
58. New catalytic non-oxidative diamination of alkenes provides a consice access to 1-p-toluenesulfonyl-3-trichloromethyl-4,5-imidazolines. Wei, H.-X.; Siruta, S.; Li, G. Tetrahedron Lett. 2002, 43, 3809-3812.
59. Electrophilic Diamination of Alkenes by using FeCl3-PPh3 Complex as the Catalyst. Wei, H.-X.; Kim, S.-H.; Li, G. J. Org. Chem. 2002, 67, 4777-4781.
60. A Convenient and Stereoselective Synthesis of b-Iodo-a-(hydroxyalkyl)acrylates. Wei, H.-X.; Gao, J.; Li, G.; Paré, P. D. Tetrahedron Lett. 2002, 43, 5677-5680.
61. Lewis Acid-Promoted Baylis-Hillman-Type Reaction of a,b-Unsaturated Ethyl Thioester with Aldehydes without the Use of a Lewis Base. Pei, W.; Wei, H.-X.; Li, G. J. Chem. Soc. Chem. Commun. 2002, 17, 1856-1857.
62. The Baylis-Hillman Condensation of a,b-Conjugate Cycloketones with Aldehydes Using Diethylaluminum Iodide Alone as the Promoter. Pei, W.; Wei, H.-X.; Li, G. J. Chem. Soc. Chem. Commun. 2002, 17, 2412-2413.
63. A Novel Three-Component Reaction via 1,4-Robust Activation of a,b-Acetylenic Ketones for Stereoselective Formations of Versatile Aldol Adducts. Wei, H.-X.; Kim, S.-H.; Li, G. Org. Lett. 2002, 4, 3691-3693.
64. The First Asymmetric Synthesis of Chiral beta-Iodo Baylis-Hillman Esters via Tandem 1,4-Conjugate Addition/Carbonyl Coupling Reactions. Xu, X.; Chen, D.; Wei, H.-X.; Li, G.; Xiao. T. L.; Armstrong, D. W. Chirality 2003, 15, 139-142.
65. Asymmetric Halo Aldol Reaction (AHA). Li, G.; Xu, X.; Chen, D.; Timmons, C.; Carducci, M. D.; Headley, A. D. Org. Lett. 2003, 5, 329-331.
66. A Novel Approach to Morita-Baylis-Hillman (MBS) Lactones via the Lewis Acid-Promoted Couplings of a,b-Unsaturated Lactone with Aldehydes. Karur, S.; Hardin, J.; Headley, A. D.; Li, G. Tetrahedron Lett. 2003, 44, 2991-2994.
67. Asymmetric synthesis of chiral b-iodo Baylis-Hillman esters using MgI2 as promoter via a one-pot three component reaction. Wei, H.-X.; Chen, D.; Xu, X.; Li, G., Paré, P. W. Tetrahedron: Asymmetry 2003, 8, 971-974.
68. Direct Electrophilic Diamination of Functionalized Alkenes without the Use of any Metal Catalysts. Chen, D.; Timmons, C.; Wei, H.-X.; Li, G. J. Org. Chem. 2003, 68, 5742-5745.
69. Novel Imidazolination Reaction of Alkenes Provides an Easy Access to New a,b-Diffrentiated 1,2-Vicinal Diamines. Pei, W.; Timmons, C.; Xu, X.; Li, G. Org. Biomol. Chem. 2003, 1, 2919-2921.
70. The Cinnamate-Based Aminohalogenation Provides an Easy Access to anti Methyl 3-Aryl-N-p-tosyl- and N-o-nosyl-aziridine-2-carboxylates. Chen, D.; Kim, S.-H.; Brian Hodges, B.; Li, G. ARKIVOC, 2003, part xii, 56-62.
71. N,N-Dichloro-2-nitrobenzenesulfonamide (2-NsNCl2) as the electrophilic nitrogen source for direct diamination of enones. Pei, W.; Wei, H.-W.; Chen, D.; Headley, A. D.; Li, G. J. Org. Chem. 2003, 68, 8404-8408.
72. The Combination of TsNH2 and NCS as Nitrogen and Chlorine Sources for Direct Diamination of Enones. Timmons, C.; Chen, D.; Xu, X.; Li, G. Eur. J. Org. Chem. 2003, 3850-3854.
73. A Novel Catalytic Reaction of Alkynes via Multiple-Site Functionalization. Karur, S.; Kotti, S. R. S. S.; Xu, X.; Cannon, J. F.; Headley, A. D.; Li, G. J. Am. Chem. Soc. 2003, 125, 13340-13341.
74. Chemiluminometric Measurement of Atmospheric Ozone with Photoactivated Chromotropic Acid, Toshio Takayanagi, Su, X.-L.; Dasgupta, P. K.; Martinelango, K.; Li, G. Al-Horr, R. S.; Shaw, R. W. Anal. Chem. 2003, 75, 5916-5925.
75. Silver Induced Enhancement of Thiochrome-based Peroxide Measurements. Li, J.; Dasgupta, P. K.; Li, G.; Motomizu, S. Anal. Chem. 2003, 75, 6753-6758.
76. Efficient nucleophilic substitution reactions of highly functionalyzed allyl halides in ionic liquid media. Kotti, S. R. S. S.; Xu, X.; Li, G.; Headley, A. D. Tetrahedron Lett. 2004, 45,1427-1431.
77. New Asymmetric Halo Aldol Reaction Provides a Novel Approach to Biologically Important Chiral Cyclothers and Cycloamines. Timmons, C.; Cannon, J. F.; Headley, A. D.; Li, G. Org. Lett. 2004, 6, 2075-2078.
78. A Polymer-Supported Phosphoramide as Lewis Base-Catalyst for Catalytic Aldol Reaction. Flowers,R. A.; Xu, X.; Timmons, C.; Li, G. Eur. J. Org. Chem. 2004, 14, 2988-2990.
79. Regio- and Stereoselective Synthesis of Vicinal Haloamino Ketones via the Catalytic Aminohalogenation Reaction of Electron Deficient Alkenes. Chen, D.; Timmons, C.; Chao, S.; Li, G. Eur. J. Org. Chem. 2004, 14, 3097-3101.
80. The First Enantioselective Halo Aldol Reaction of Allenoates and Aldehydes. Chen, D.; Timmons, C.; Liu, J.; Headley, A. D.; Li, G. Eur. J. Org. Chem. 2004, 15, 3330-3335.
81. One-pot stereoselective synthesis of anti 3-alkyl and 3-aryl-N-p-tosyl-aziridine-2-ketones and 3-aryl-N-p-tosyl-aziridine-2–carboxylates. Chen, D.; Timmons, C.; Guo, L.; Xu, X.; Li, G. Synthesis, 2004, 2479-2484.
82. The Combination of 2-NsNH2/NCS and MeCN as the Nitrogen Sources for the Regio- and Stereoselective Diamination of a,b-Unsaturated Ketones, Timmons, C.; Chen, D.; Barney, E.; Kirtane, S.; Li, G. Tetrahedron 2004, 60, 12095-12099.
83. MgI2-Catalyzed Halo Aldol Reaction: a Practical Approach to (E)-b-Iodovinyl-b'-hydroxyketones, Wei, H.-X.; Timmons, C.; Farag, M. A.; Paré, P. W.; Li, G. Org. & Biomol. Chem. 2004, 2 (20), 2893-2896.
84. Ionic Liquid Media Resulted in More Efficient Regio- and Stereoselective Aminohalogenation of Cinnamic Esters, Kotti, S.R.S.S.; Xu, X.; Wang, Y.; Headley, A. D.; Li, G. Tetrahedron Lett. 2004, 45, 7209-7212.
85. Z/E Stereoselective Synthesis of b-Bromo Baylis-Hillman Ketones using MgBr2 as Promoter via a One-pot Three-Component reaction, Wei, H.-X.; Jasoni, R. L.; Hu, J.; Li, G.; Paré, P. W. Tetrahedron 2004, 60 (45),10233-10237.
86. Stereoselective Aldol Coupling to Synthesize (Z)-a-(hydroxyalkyl)-b-Iodoacrylates using Magnesium Diiodide (MgI2) as Promoter, Wei, H.-X.; Hu, J.; Jasoni, R. L.; Li, G.; Paré, P. W. Helv. Chim. Acta. 2004, 87(9), 2359-2363.
87. Ionic Liquid Media Resulted in the First Asymmetric Aminohalogenation Reaction of Alkenes. Xu, X.; Kotti, S.R.S.S.; Liu, J.; Cannon, J. F.; Headley, A. D.; Li, G. Org. Lett. 2004, 6, 4877-4879.
88. Construction of a Bacterial Autoinducer Detection System in Mammalian Cells, Shiner, E. K.; Reddy, S.; Timmons, C.; Li, G.; Williams, S. C.; Rumbaugh, K. P. Biol. Proced. Online, 2004, 6, 268-276.
89. Lewis Acid-Promoted Asymmetric Umpolung Reaction via the Use of Chiral N-Sulfinyl Imines as the Electrophiles, Xu, X.; Liu, Y.; Chen, D.; Timmons, C.; Li, G. Eur. J. Org. Chem. 2005, 1805-1809.
90. The First Asymmetric Catalytic Halo Aldol Reaction of b-Iodo Allenoates with Aldehydes by using Chiral Salen Catalyst, Chen, D.; Kotti, S.R.S.S.; Guo, L.; Li, G. Tetrahedron Asymmetry 2005, 16, 1757-1762.
91. Functionalization of a,b-Unsaturated Esters and Ketones: A Facile and Highly Stereoselective One-Pot Approach to N-Protected a,b-Dehydroamino Acid Derivatives, Chen, D.; Guo, L.; Liu, J.; Kirtane, S.; Cannon, J. F.; Li, G. Org. Lett. 2005, 7, 921-924.
92. Asymmetric Halo Mannich Type Reaction Provides Access to Pyrrolidines and b-Proline Derivatives, Timmons, C.; Guo, L.; Liu, J.; J. F. Cannon; Li, G. J. Org. Chem. 2005, 70, 7634-7639.
93. The Enantioselective Halo Aldol Reaction Utilizing Cyclopropyl Ketone Derived Enolates, Timmons, C.; Li, G., Tetrahedron Lett. 2005, 46, 6949-6952.
94. Manganese (IV) oxide-catalyzed electrophilic diamination of alkenes provides an easy synthesis of a,b-diamino derivatives for peptidomimetic studies. Cody Timmons, Lauren M. Mcpherson, Dianjun Chen, Han-Xun Wei; Guigen Li J. Peptide Res., 2005, 66, 249–254.
95. Aza Diels-Alder Reaction Utilizing 4-iodo-2-trimethylsilyloxy-butadiene. Cody Timmons, Lauren McPherson, James Mills, Guigen Li Tetrahedron, 2005, 61, 11837-11842.
96. The Design and Synthesis of C-2 Substituted Chiral Imidazolium Ionic Liquids from Amino Acid Derivatives. Bukuo Ni, Allan D. Headley, Guigen Li. J. Org. Chem. 2005, 70, 10600-10602.
97. New Developments on Catalytic Negishi Cross-Coupling Reactions. Dianjun (David) Chen, S.R.S. Saibabu Kotti; Guigen Li, CHEMTRACTS-Organic Chemistry, 2005, 18, 193-199.
98. Allylic Alkylation Reactions With Acyclic Cu-Enolates. Cody Timmons; Guigen Li, CHEMTRACTS-Organic Chemistry, 2005,18, 215-220.
99. Regio and stereoselective synthesis of anti 3-chloro-1,3-diaryl-2-(o-nirobenzenesulfonamido)-3-propan-1-ones through catalytic aminohalogenation reaction of a,b-unsaturated ketones. Junying Liu, Yining Wang; Guigen Li. Eur. J. Org. Chem. 2006, 14, 3112-3115.
100. FeCl3-Catalyzed Aminohalogenation of Arylmethylenecyclopropanes and Arylvinylidenecyclopropanes and the Corresponding Mechanism Studies. Qingjiang Li; Min Shi; Cody Timmons; Guigen Li. Org. Lett. 2006, 8, 625-628.
101. Vicinal diamino functionalities as privileged structural elements in biologically-active compounds and exploiting their synthetic chemistry. S. R. S. Saibabu Kotti, Cody Timmons, Guigen Li. Chem. Biol. & Drug Design, 2006, 67, 101-114.
102. Highly Z/E Stereoselective Approach to b-Iodo Aza Morita-Baylis-Hillman Adducts. Cody Timmons, Adiseshu Kattuboina, Soham Banerjee, Guigen Li. Tetrahedron 2006, 62, 7151-7154.
103. Novel Approach to Multifunctionalized Homoallylic Alcohols via Regioselective Ring Opening of Aryl Oxiranes with 3-Iodo Allenoates, Adiseshu Kattuboina, Parminder Kaur, Cody Timmons and Guigen Li, Org. Lett. 2006, 8, 2771-2774.
104. Caenorhabditis elegans Senses Bacterial Autoinducers, Beale, E., Li, G., Tan, M.W., Rumbaugh, K. P. Appl Environ Microbiol. 2006, 72, 5135-7.
105. Pseudomonas aeruginosa Autoinducer Modulates Host Cell Responses Through Calcium Signaling, Shiner, E.K., Terentyev, D., Bryan, A., Sennoune, S., Martinez-Zaguilan, R., Li, G., Gyorke, S., Williams, S. C. and Rumbaugh, K. P. Cellular Microbiol. 2006, in press.
106. Aziridination of Alkenes using N,N-Dichloro-p-toluenesulfonamide as Nitrogen Source and Palladium as Catalyst, Jianlin Han, Yufeng Li, Sanjun Zhi, Yi Pan, Cody Timmonsc and Guigen Li, Tetrahedron Lett. 2006, in press.
107. Acrolein, Timmons, C.; Kotti, S.R.S.S.; Li, G. The Encyclopedia of Reagents for Organic Synthesis [EROS], (Ed., L. Paquette, John Wiley and Sons), 2006, in press.
108. Ionic Liquid, [bmim][N(SO2CF3)2], Resulted in the First Catalyst-Free Aminohalogenation of Electron-Deficient Alkenes, Yining Wang, Bukuo Ni, Allan D. Headley and Guigen Li, Adv. Synth. & Cat. 2006, submitted.
109. CuCl-Catalyzed Regio- and Stereoselective Aminohalogenation of a,b-Unsaturated Nitriles, Jianlin Han, Sanjun Zhi, Leyong Wang, Yi Pan and Guigen Li, J. Org. Chem. 2006, submitted.