Department of Physiology

Professor John Orem, Chairperson.

Professors Davies, Lutherer, McGrath, Nathan, Sabatini, and Wesson; Associate Professors Fowler, Györke, Pressley, and J. Strahlendorf; Assistant Professors Martinez-Zaguilan and Sarvazyan; Joint Professors Heavner, Janssen, Jumper, Kurtzman, Laski, and Neely.

This department offers study in the following graduate degree programs: PHYSIOLOGY, Master of Science and Doctor of Philosophy. The program is designed primarily to train persons for careers in biomedical research and/or teaching in medical institutions or industry, but can accommodate those interested in alternative careers in physiology. Faculty research programs are diverse, encompassing the general areas of systemic, cardiovascular, renal, and neurophysiology. Specific areas include membrane biophysics, Ca++ channels and other membrane transporters, pH and Ca++ homeostasis, Na+/K+ ATPase, excitation-contraction coupling, oxygen free radicals and cell injury, apoptosis, neuronal protective mechanisms, particle toxicology, cerebral blood flow, hypertension, shock, sleep and control of respiratory and cardiovascular function.

Advanced courses in specialized areas are taught under the topics course and are designed to fit a student's specific needs.

Applicants should have a demonstrated interest in research and preferably have identified an area for their dissertation research. All candidates for graduate degrees who hold assistantships must fulfill certain requirements while appointed as assistants.

GPHY 5803 is normally a prerequisite for all courses in or above the 6000 level but may be waived for students in other programs with approval of the instructor. Enrollment in GPHY 5803 is limited to students admitted to degree programs and requires approval by the thesis director and the department chairperson.

Courses in Physiology. (GPHY)

5302. Human Physiology: Cellular and Integrated Mechanisms (3:3:0). Prerequisite: College biology and consent of instructor. An introduction to the physiology of mammalian organ systems placing emphasis on the human. Subject matter includes membrane transport, muscle, cardiovascular, respiratory, renal, water and electrolyte balance, gastrointestinal, and endocrine physiology as well as neurophysiology.

5350. Laboratory Methods in Physiology (3:0:3). Fundamental principles of physiology are explored through a series of hands-on laboratory exercises. Numerous techniques common to research in many fields will be introduced.

5803. Medical Physiology (8:7:4). A study in human physiology emphasizing body-controlling systems and their interrelationships. Pathological mechanisms are also stressed.

5910. Integrated Neurosciences (9:8:1). This cooperative, interdepartmental effort offers a detailed study of the nervous system. Students examine both gross and fine structure and function from the subcellular through the behavioral level. (GIDN 5910)

6000. Master's Thesis (V1-6).

6105, 6205, 6305. Topics in Physiology (1:1:0; 2:2:0; 3:3:0). Prerequisite: Consent of instructor. Advanced training in a specialized area of physiology. May be repeated for credit with change in content.

6210. Advanced Cardiovascular Physiology (2:2:0). Prerequisite: GPHY 5803 and consent of instructor. Advanced level coverage of topics in cardiovascular physiology with much material being covered in reviews of the research literature.

6304. Health Effects of Environmental Pollutants (3:3:0). Prerequisite: College biology and chemistry and consent of instructor. The physiological changes and potential health effects associated with energy usage and development. Emphasis is on understanding mechanisms of actions, effects of extreme environmental and occupational conditions (i.e., altitude, temperature, pollution), and risk evaluation. Offered even years only.

6311. Cellular and Molecular Physiology (3:3:0). Prerequisite: GIDN 5910 or GPHY 5502 or consent of instructor. The study of the structure and function of ion channels and transporters, excitation-contraction coupling, and mechanisms of cell damage and death.

6314. Membrane Biophysics (3:3:0). Students are introduced to the mechanisms of ion transport through membrane channels; models of membrane excitability; molecular structures of ion channels and their physiological functions.

6315. Physiology of Neuroeffector Systems (3:3:0). A consideration of adrenergic, cholinergic, histaminic, and serotonin receptor systems and their physiological applications. Offered summers even years only.

6704. Cell Function and Regulation (7:7:0). Topics include structure and function of membranes and organelles, mechanisms of transcription and translation, and regulation of cellular processes including both the endocrine and nonendocrine aspects. (GANM 6704, GBCH 6704)

7000. Research (V1-12).

7101. Physiology Seminar (1:1:0). This weekly seminar series provides invited speakers from this and other departments as well as other universities and laboratories with the opportunity to present their current research in some area of physiology.

7102. Readings in Physiology (1:1:0). Students review literature on special topics of research. (Students may be assigned or may select these topics.) May be repeated for credit.

7103. Supervised Teaching in Physiology (1:1:0). Prerequisite: GPHY 5803. Supervised teaching experience including leading laboratory groups and small-group discussions and presenting lectures in some departmental courses (all under faculty supervision).

8000. Doctor's Dissertation (V1-12).

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