Texas Tech University

How Scientific Research Transitions from the Lab to Become a Tool to Improve Patient Care

By: Nicole Lundberg 

The story started with a simple research presentation.

Suhas Pol, a research assistant professor in the Department of Mechanical Engineering at Texas Tech University, asked Kerry Gilbert, professor and director of the Clinical Research Anatomy Laboratory, at the Texas Tech University Health Sciences Center (TTUHSC), to give a presentation related to fluid dynamics of nerve tissue. During the presentation, Gilbert mentioned a research problem that caught Pol's attention.

Gilbert and his colleagues Phillip Sizer, professor and director of the Musculoskeletal Research Laboratory at TTUHSC, and Richard Ellis, senior lecturer at Auckland University of Technology in New Zealand, wanted to measure and predict tissue kinematics or the amount of displacement and strain on nerve tissue in live patients. The ability to measure and predict strain in nerve, muscle, tendon and ligament tissue would help physicians and physical therapists examine, prescribe and monitor treatment outcomes for people with compromised tissues.

Unfortunately, the currently existing methods for accurately measuring tissue kinematics are relatively invasive, making them impractical for clinical applications.

"We were stuck," Gilbert said. "When we mentioned the problem in our presentation, our mechanical engineering colleagues came on board and said, 'we have a technology that could help you solve this problem.'"

Pol said his department had an experimental tool, originally used for wind energy research, that he believed could be applied to research on tissue.

TK Quant
The Office of Research Commercialization encouraged the researchers to enter the National Science Foundation's Regional I-Corps program, hosted at Texas Tech's Innovation Hub at Research Park.

"There is nothing new about the technology itself," Pol said. "However the application and the processing are new."

After developing and applying the technology for two years, Pol and the rest of the team realized that the process had commercial potential.

"When we originally met to discuss the research question, there was no expectation for commercialization. It was just a collaboration between Texas Tech, TTUHSC, and Auckland University of Technology," Pol said. "Because he had gone through the commercialization process for other technologies, the team determined that they should disclose their technology and process to the Texas Tech Office of Research Commercialization (ORC)."

While Gilbert and Ellis continued with the initial research efforts, Sizer and Pol worked diligently to develop the disclosure document. The Office of Research Commercialization encouraged the researchers to enter the National Science Foundation's Regional I-Corps program, hosted at Texas Tech's Innovation Hub at Research Park. The program is a national initiative that helps researchers identify paths to taking their inventions and discoveries to the marketplace.

Because Pol had been through the I-Corps program at the national level for other technologies, he knew the program would enable the team to understand whether the technology that was designed for research had commercial value. As part of the program participants develop business plans and conduct interviews to identify potential markets.

"NSF I-Corps forces you to get out of the building," he said. "You have a technology you are comfortable with in your own research area. That has value, but to find whether a technology is commercially viable, you have to talk to professionals in fields other than yours."

At this point, the research team included an entrepreneurial lead, Kinyata Cooper, a doctoral student in the TTUHSC Rehabilitation Sciences Program. Over three weeks, the team interviewed 29 professionals from a variety of fields and cities. The purpose of these interviews was not to describe the technology in order to see whether people wanted to buy it. Instead, interviewers sought to understand the problems that people in other fields face and recognize how or whether the technology in question provides a solution to that distinct problem.

Although the technology offered value to many clinical fields, the researchers had not predicted one of area of medicine that seemed to have the greatest need for the technology, Sizer said. Obstetrics and gynecology (OB-GYN) specialists were particularly interested in using the technology to measure scar tissue following a caesarean section. This assessment tool may provide OB-GYN specialists to more accurately determine the risk associated with future natural child births and limit the number of emergency caesarean section surgeries necessary.

"The Regional I-Corps process was productive," Sizer said. "We believe that if you follow the steps they encourage you to take, you have a better understanding of the customer segment related to your technology. If we had not embraced the process, we might have marketed our product to a group of clinicians that ultimately could not care less about what we had to offer. Customer discovery is important to any business and our Regional I-Corps experience helped us understand that point."

Although commercialization was not the team's original plan, they said they would encourage fellow researchers to participate in the I-CORPS program.

"Going through the process slows things down a bit, but the end result is dramatically different than what you would have otherwise imagined," Gilbert said.

 

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