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Spring 2014

Certain Fat Could Help Humans Lose Weight

by John Davis

Certain Fat Could Help Humans Lose Weight

Discovery could lead to supplements that will boost metabolism and decrease muscle fatigue.

Meet the Expert

Chad Paton

Chad Paton is an assistant professor of nutritional biochemistry in the College of Human Sciences.

Biochemical and Molecular Nutrition Lab

Biochemical and Molecular Nutrition Lab

Chad Paton is a researcher in the Biochemical and Molecular Nutrition Lab in the Department of Nutrition. The lab is focused on understanding the role of nutritional factors in regulating metabolic activity.

To find out more information about a specific study or the lab’s testing services, please contact Chad Paton at chad.m.paton@ttu.edu.

A diet high in a certain type of fat may actually increase metabolism, according to recent research by Texas Tech University nutrition scientists.

After studying genetically modified mice, the discovery could lead to supplements and a diet regimen that will increase metabolism and decrease muscle fatigue in humans.

The research was published in the peer-reviewed journal, The Journal of Lipid Research.

Chad Paton, an assistant professor of nutritional biochemistry in the Department of Nutrition, Hospitality and Retailing, said he and colleagues were curious why skeletal muscles of obese people contained a certain type of enzyme that breaks down saturated fats.

To test what that enzyme did, Paton’s lab and colleagues from the University of Wisconsin–Madison genetically modified mice so that their muscles would constantly produce the enzyme.

“We used a transgenic mouse model,” explained Paton. “We took the gene that makes the enzyme that’s not normally expressed and took away its regulation to make it active all the time. What we found in those animals is that they had a hypermetabolic rate compared to the wild mice, increased energy consumption and greatly increased exercise capacity.”

The enzyme, called stearoyl-CoA desaturase-1 (SCD1), converts saturated fat into monounsaturated fat, which is easier to metabolize. The liver will produce this enzyme, depending on the fat content of the food consumed, he said. Fatty adipose tissue produces it all the time as a way of regulating itself.

Only in heavily exercised muscle tissue or in the case of obesity does skeletal muscle produce the enzyme, he said.

After looking at skeletal muscles of the genetically modified mice compared to that of the wild mice, Paton and his team discovered higher levels of polyunsaturated fats, particularly linoleic acid, received only through diet.

Higher levels of linoleic acid could only mean one thing–the modified mice were eating more food. But Paton’s team found that the modified mice weighed less than the wild mice.

On top of that, their ability to exercise increased.

Researchers Akchurin and Lee analyze data from the CERN project, for which Texas Tech provided the calorimeters.

By comparing skeletal muscles of genetically modified mice to wild mice, Paton and his colleagues say a diet high in a certain type of fat may actually increase metabolism and decrease muscle fatigue in humans.

“We found in the genetically modified animals that they had a hypermetabolic rate,” he said. “They were increasing their energy consumption, and they experienced greatly increased exercise capacity. For example, on the exercise wheels, normal mice fatigue after seven to 10 minutes. These genetically modified animals wouldn’t fatigue for about 70 minutes. So they were running a lot longer. Sedentary mice looked more like exercise-trained mice. That really made us look in a lot more detail what was happening in the skeletal muscle.”

By looking at the muscle tissues, Paton and his team members discovered a trend.

More of the SCD1 enzyme, and a greater appetite by the mice, meant more linoleic acid in the tissues. The linoleic acid switched on part of the muscle cells’ DNA that encouraged the cells to make more mitochondria and to turn on a protein that encouraged the cells to burn off excess energy from the extra food as heat–a process called uncoupling.

Humans store unused energy as fat, Paton said. And while that helped our ancestors survive, it can lead to obesity for some people in today’s world of plentiful food.

While genetically modifying humans isn’t an option, Paton said this experiment could hold useful information for supplementing human diets to achieve the same results.

“That’s where we have taken our research from this,” he said. “You can’t change the human genome, but that gives us insight if you could activate the same part of the DNA in human skeletal muscles that burn off excess energy as heat instead of storing it. Perhaps it’s a supplement people could take that will turn on the cells’ metabolic machinery, burn off energy and increase mitochondria.”

John Davis is a Senior Writer in the Office of Communications & Marketing at Texas Tech University.

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Sep 24, 2014