Texas Tech University

Michael J. San-Francisco, Retired

Professor Molecular Microbiology
Not accepting new students


Phone: 1(806)834-1449

Professor:Molecular Microbiology; Microbe-Host Interactions

Academic Professor, Department of Microbiology and Immunology, Texas Tech Health Sciences (TTUHSC) 

Director, Clark Scholars Program, www.clarkscholars.ttu.edu

Associate Program Director,
Texas Tech University/Howard Hughes Medical Institute Science Education Program, www.hhmi.ttu.edu

Dr. San Francisco

2020 09/01-09/2021         Interim Dean College of Arts & Sciences

2014 01/01-8/2020            Dean, Honors College

2012-12/2013                        Interim Vice President for Research

2010-9/2012                          Associate Vice President for Research

2008-6/2010                         Associate Dean, Honors College, Texas Tech University

2008-2015                              Associate Director, TTU/HHMI Science Education Program

2006-2008                             Director, TTU/Howard Hughes Medical Institute Science Education Program

2004-present                       Professor, Biological Sciences, Texas Tech University

2001-2009                             Faculty Director Joint Admissions Medical Program (State of Texas)

2001-present                        Adjunct Professor, Microbiology and Immunology, Texas Tech University HSC

1997-1998                               Interim Chair, Department of Biological Sciences, Texas Tech University

1996-2021                              Director, Clark Scholar Program, Texas Tech University

1996-2003                             Associate Professor, Biological Sciences, Texas Tech University

1990-1996                             Assistant Professor, Biological Sciences, Texas Tech University

  • Ph.D., Biology, Boston University (1984)
  • M.S., Biology, Boston University (1980)
  • B.Sc, University of Agricultural Sciences, Bangalore, India (1977)

Research Interests

Bacterial and Fungal Plant and Animal host-microbe interactions

Atmospheric Microbiology

Environmental Microbiology

Selected Publications


Elmassry, M. M., Bisht, K., Colmer‐Hamood, J. A., Wakeman, C. A., San Francisco, M. J., & Hamood, A. N. (2021). Malonate utilization by Pseudomonas aeruginosa affects quorum‐sensing and virulence and leads to formation of mineralized biofilm‐like structures. Molecular Microbiology (In Press)

Ganapathy, S., Parajulee, M., San Francisco, Zhang, H, Bilimoria S. 2021. Novel-iridoviral kinase induces mortality and reduces performance of green peach aphids (Myzus persicae) in transgenic Arabidopsis plants. Plant Biotechnology Reports 15: 13-25

Elmassry, M M, N. Ray, S. Sorge, J. Webster, K. Merry, A. Caserio, D. J Vecellio, C. Kruczek, S. Dowd, K. Ardon-Dryer, J. Vanos, M. J. San Francisco. 2020. Investigating the culturable atmospheric fungal and bacterial microbiome in West Texas: Implication of dust storms and origins of the air parcels. FEMS Microbes, xtaa009, https://doi.org/10.1093/femsmc/xtaa009

Elmassry, M.M, Mudaliar N, Colmer-Hamood J, San Francisco M, Griswold J, Dissanaike S and Hamood A. New markers for sepsis caused by Pseudomonas aeruginosa during burn infection. 2020. Metabolomics 16:40 https://doi.org/10.1007/s11306-020-01658-2

Silva, S., Elmassry, M, Matz, L and San Francisco, M. 2019. Characteristics of monolayer formation in vitro by the chytrid Batrachochytrium dendrobatidis. Biofilm, https://doi.org/10.1016/j.bioflm.2019.100009

Elmassry, M.M, Mudaliar N, Kottapalli K, Dissanaike S, Griswold J, San Francisco M, Colmer-Hamood J and Hamood A. 2019. Pseudomonas aeruginosa alters its transcriptome related to carbon metabolism and virulence as a possible survival strategy in blood from trauma patients. mSystems00312-18R1.

Thekkiniath J, R Ravirala and M San Francisco, 2016. Multidrug Efflux pumps in the genus Erwinia: Physiology and regulation of efflux pump gene expression in Progress in Molecular Biology and Translational Science, vol 142, Academic Press, (San Francisco and San Francisco eds).

San Francisco, M and San Francisco B, (eds) 2016. Progress in Molecular Biology and Translational Science, vol 142 Host-Microbe Interactions, Academic Press 325pp.

Y. Li, K.-W. Hsiao, C. A. Brockman, D. Y. Yates, R. M. Robertson-Anderson, J.A. Kornfield, M. J. San Francisco, C. M. Schroeder and G. B. McKenna*, 2015. When Ends Meet: Circular DNA Stretches Differently in Elongational Flows. Macromolecules, 48, 5997-6001.

Thekkiniath J, S San Francisco, M Zabet K Rao. M Pasham and MJ San Francisco. 2015.  Quantitative proteomics of an amphibian pathogen, Batrachochytrium dendrobatidis following exposure to thyroid hormone. PloS One-DOI: 10.1371/journal.pone.0123637.

Thekkiniath J, M Zabet-Moghaddam, SK San Francisco and MJ San Francisco, 2013. A novel subtilisin-like serine protease of Batrachochytrium dendrobatidis is induced by thyroid hormone and degrades antimicrobial peptides. Fungal Biol 117:451-461.

Pan X, KM Ochoa, MJ San Francisco, SB Cox, K Dixon TA Anderson and GP Cobb, 2013.  Absorption, distribution, and biotransformation of hexahydro-1,3,5-trinitro-1,3,4-triazine in B6C3F1 Mice (Mus musculus). Env Tox and Chem 32:1295-1303.

Charkowski A, Blanco C, Condemine G, et al. MJ San Francisco, et al. 2012. The role of secretion systems and small molecules in soft-rot Enterobacteriaceae pathogenicity. Annu Rev Phytopathol. 50:425-449.

Phillips CD, G Phelan, SE Dowd, MM McDonough, AW Ferguson, JD Hanson, L Siles, N Ordonez-Garcia, M San Francisco, RJ Baker, 2012. Microbiome analysis among bats describes influences on host phylogeny, life history, physiology and geography. Mol. Ecol doi 10.1111/j/1365-294X2012.05568x.

Shapard EJ, AS Moss and MJ San Francisco, 2012. Batrachochytrium dendrobatidis can infect and cause mortality in the nematode Caenorhabditis elegans. Mycopatholiga 173:121-126.

Glasner JD, CH Yang, S Reverchon, N Hugouvieux-Cotte-Pattat, G Condemine, JP Bohin, F Van Gijsegem, S Yang, T Franza, D Expert,G  Plunkett 3rd, MJ San Francisco, AO Charkowski, et al., FR Blattner, NT Keen, NT Perna , 2011. Genome sequence of the plant pathogenic bacterium Dickeya dadantii 3937 J Bacteriol. 193:2076-2077.

Barabote RD, J Thekkiniath, RE Strauss, G Vediyappan, JA Fralick, MJ San Francisco, 2011. Xenobiotic Efflux in Bacteria and Fungi: A Genomics Update in Advances in Enzymology and Related Areas of Molecular Biology: 237–306, 2011. Published Online : 23 FEB, DOI:10.1002/9780470920541.ch6.

Moss, AS, N. Carty, MJ San Francisco Identification and partial characterization of an elastolytic protease in the amphibian pathogen Batrachochytrium dendrobatidis, 2010. Diseases of Aquatic Organisms 92:149-158

Hughes MK, S Yanamala, MJ San Francisco, GH Loneragan, MF Miller, and MM Brashears, 2010.  Reduction of multidrug-resistant and drug-susceptible Salmonella in ground beef and freshly harvested beef briskets after exposure to commonly used industry antimicrobial interventions.  J Food Prot 73:1231-1237.

Davinic M, N Carty, JA Colmer-Hamood, MJSan Francisco, and AN Hamood, 2009. The role of Vfr in regulating exotoxin A production by Pseudomonas aeruginosa. Microbiology 155:2265-2273.

Yang S, Q Peng, MJ San Francisco, Y Wang, Q Zeng, CH Yang. 2008. Type III secretion system genes of Dickeya dadantii 3937 are induced by plant phenolic acids. PLoS ONE 3(8): e2973 doi:10.1371/journal.pone.0002973.

Moss SA, N Reddy, I Dortaj, MJ San Francisco, 2008.  Chemotaxis of the amphibian pathogen Batrachochytrium dendrobatidis and its response to a variety of attractants.  Mycologia 100:1-5.

Ravirala, R, RD Barabote, D Wheeler, S Reverchon, O Tatum, C Malouf, H Lui, P Hedley, L Pritchard, P Birch, I Toth, P Payton, and MJ San Francisco, 2007. Phenolic acids induce efflux pump gene expression in Erwinia chrysanthemi 3937. Mol. Plant-Microbe Interact. 20:313-320.

Dowd SE, K Killinger-Mann, J Blanton, MJ San Francisco, and MM Brashears, 2007. Positive adaptive state: Microarray evaluation of gene expression in Salmonella enterica Typhimurium upon exposure to sub-therapeutic levels of nalidixic acid. Foodborne Pathog Dis. Summer;4(2):187-200.

Pan X, MJ San Francisco, C Lee, KM Ochoa, X Xu, B Zhang, GP Cobb, 2007. Examination of the mutagenicity of RDX and its N-nitroso metabolites using the Salmonella reverse mutation assay. Mutation Res, 629:64–69.

Pan X, B Zhang, JN Smith, MJ San Francisco, TA Anderson, GP Cobb. 2007. N-nitroso compounds produced in deer mouse (Peromyscus maniculatis) gastrointestinal tracts following RDX exposure. Chemosphere, 67(6): 1164-1170.

Pan X, B Zhang, MJ San Francisco, GP Cobb. 2007. Characterizing viral microRNAs and its application on identifying new microRNAs in viruses. J Cell Physiol, 211:10-18.

Jaynes W., R Zartman, CJ Green, MJ San Francisco, and JC Zak, 2005. Castor toxin adsorption to clay minerals. Clay and Clay Minerals 53:267-276.

Westfall L, AM Luna, MJ San Francisco, S P Diggle, K E Worrall, P Williams, M Camara and AN Hamood, 2004.The Pseudomonas aeruginosa global regulator MvaT specifically binds to the ptxS upstream region and enhances ptxS expression. Microbiology 150:3797-3806.

Boroda E, WF Jaynes, R E Zartman, CJ Green, MJ San Francisco, and JC Zak, 2004. Enzyme-linked immunosorbent assay (ELISA) measurement of castor toxin in soils. Comm. Soil Science Plant Anal. 35(7&8):1185-1195.

Barabote R, OL Johnson, E Zetina, S San Francisco, J Fralick, and MJ San Francisco, 2003. Erwinia chrysanthemitolC can complement defects of an Escherichia tolC mutant and is important in plant infection. J. Bacteriol. 185:5772-5778.

Thorvilson H, D Wheeler, B Bextine, and MJ San Francisco, 2002. Development of Beauveria bassiana formulations and genetically marked strains as a potential biopesticide for imported fire ant control.  Southwest. Entomol. Suppl. 25: 19-29.

Schraeder M, HG Thorvilson, and MJ San Francisco, 2002.  Bioassay evaluation of transgenic strains of Beauveria bassiana against Solenopsis invicta Buren.  P. 81-84.  In Suiter, D., S. Diffie, and B. Sparks (eds).  Proceedings of the 2002 Imported Fire Ant Conference, Athens, GA., March 24-26, 2002.  173 pp.

Valmeekam V, Y-L Loh and MJ San Francisco, 2001.  Control of exuT Activity for galacturonate transport by the negative regulator ExuR in Erwinia chrysanthemi EC16.  Mol. Plant-Microbe Interact. 14:816-820.

Duarte X, CT Anderson, M Grimson, RE Strauss, LS Gollahon and MJ San Francisco, 2000.  Erwinia chrysanthemi strains cause death of human gastrointestinal cells in culture and express an intimin-like protein. F.E.M.S. Microbiol. Lett. 190:81-86.

Haseloff BJ, TL Freeman, V Valmeekam, MW Melkus, MS Valachovich and MJ San Francisco, 1998. The exuT gene of Erwinia chrysanthemi  EC16, nucleotide sequence, expression, localization and relevance of the gene product.  Mol. Plant-Microbe. Interact. 11:270-276.

Valmeekam V, MW Melkus, BJ Haseloff and MJ San Francisco, 1997. Transport of plant cell wall molecules in phytopathogenic bacteria.  Trends in Plant Pathology. 1: 71-75.

San Francisco, MJ, Z-X Xiang and RW Keenan, 1996. Characterization of the digalacturonic acid uptake system in Erwinia chrysanthemi. Mol Plant-Microbe Interact.  9:144-147.

Podila, GK, E Rosen, MJ San Francisco, and PE Kolattukudy, 1995. Targeted secretion of cutinase in Fusarium solani f. sp. pisi and ColletotrichiumgleosporoidesPhytopathology85:238-242.

Freeman TL, and MJ San Francisco.  1994.  Cloning of a galacturonic acid uptake gene from Erwinia chrysanthemi EC16.  F.E.M.S. Micro. Letters118:101-106.

San Francisco MJ and RW Keenan, 1993. Uptake of galacturonic acid in Erwinia chrysanthemi EC16.  J.  Bacteriol.  175:4563-4567.

San Francisco MJ, DM Joseph and RM McCasland, 1993.  Uptake of degradable plant cell wall molecules by phytopathogenic bacteria.  The Southern Association of Agricultural Scientists Bulletin (Biochemistry and Biotechnology), 6:17-21.

San Francisco MJ, CL Hope, JB Owolabi, and BP Rosen, 1990.  Identification of the metalloregulatory element of the plasmid-encoded arsenical resistance operon.  Nucleic Acids Research18 (3), 619-624.

San Francisco MJ, LS Tisa and BP Rosen, 1989.  Identification of the membrane component of the anion pump encoded by the arsenical resistance operon of R-factor R773.  Molecular Microbiology3:15-21.

San Francisco MJ, C-M Chen and BP Rosen, 1988. Identification of the membrane component of the anion pump encoded by the arsenical resistance operon of R-factor R773, in "Calcium and Phosphate Transport in Health and Disease" (Bonner, F. and Peterlik, M., eds), pp 311-316.  Alan R. Liss, NY.

Perlin D, MJ San Francisco, C. Slayman and BP Rosen, 1986.  H+/ATP stoichiometry of proton pumps from Neurospora crassa and Escherichia coli.  Arch.  Biochem.  Biophys248: 53-61.

San Francisco MJ and GR Jacobson, 1986.  Glucose uptake and phosphorylating activities in two species of slow-growing RhizobiumF.E.M.S. Micro. Lett. 35: 71-74.

San Francisco, MJ and GR Jacobson, 1985.  Uptake of succinate and malate in cultured cells and bacteroids of two slow-growing species of Rhizobium   J. Gen. Microbiol131: 765-773.

San Francisco, MJ and GA Cooper-Driver, 1984. Antimicrobial activity of phenolic acids in Pteridium aquilinumAmerican Fern Journal74: 87-95.


San Francisco, M and B. San Francisco, 2016. Host-Microbe Interactions, Vol 142 in Progress in Molecular Biology and Translational Science,

Academic Press, pp 325.


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