Publications
PEER REVIEWED ARTICLES
2025
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1. |
Firdaus NHW, Mallick B, Nandakumar KS, Shakya AK*. Advantages of |
2. |
GKV Prabhu, AK Shakya, HS GIll. Microneedles Coated with Cows Milk Proteins: Immunogenicity, Stability, and Safety Assessment. Molecular Pharmaceutics 2025, 22, 6, 2858–2867. (https://doi.org/10.1021/acs.molpharmaceut.4c01136) |
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2024 |
3. |
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2023
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4. |
AK Shakya*, KS Nandakumar. Polymer Chemistry Defines Adjuvant Properties and Determines the Immune Response against the Antigen or Vaccine.Vaccines 2023, 11(9), 1395. (*Corresponding author) (https://doi.org/10.3390/vaccines11091395) |
5. |
AK Shakya*, B Mallick, KS Nandakumar. A Perspective on Oral Immunotherapeutic Tools and Strategies for Autoimmune Disorders. Vaccines 2023, 11(6), 1031. (*Corresponding author) (https://doi.org/10.3390/vaccines11061031) |
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2022
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6. |
AK Shakya*. Functionalized cryogel monoliths for fast and selective separation of nucleic acids directly from the crude lysate. Biomedical Chromatography, 2022;36:e5333. (*Corresponding author) (https://doi.org/10.1002/bmc.5333) |
7. |
LD Nesovic, AK Shakya$, HS Gill. Treating allergies via skin-recent advances in cutaneous allergen immunotherapy. Advanced Drug Delivery Reviews, 2022, 114458. ($Sharing first authorship). (https://doi.org/10.1016/j.addr.2022.114458) |
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8. |
JJ Landers, KW Janczak, AK Shakya, V Zarnitsyn, SR Patel, JRB Jr, HS Gill, JJ OKonek. Targeted allergen-specific immunotherapy within the skin improves allergen delivery to induce desensitization to peanuts. Immunotherapy, 2022, 10.2217. (https://doi.org/10.2217/imt-2021-0206) |
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2020 |
9. |
AK Shakya, CH Lee, HS Gill. Microneedles mediated allergen-specific immunotherapy for the treatment of airway allergy in mice. Molecular Pharmaceutics, 2020;17:3033-3042. (https://doi.org/10.1021/acs.molpharmaceut.0c00447) |
2019 |
10. |
AK Shakya, RS Ingrole, G Joshi, MdJ Uddin, S Anvari, CM Davis, HS Gill. Microneedles coated with peanut allergen enable desensitization of peanut-sensitized mice. Journal of Controlled Release, 2019;314:38-47. (https://doi.org/10.1016/j.jconrel.2019.09.022) |
2018
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11. |
AK Shakya, CH Lee, MdJ Uddin, HS Gill. Assessment of Th1/Th2 bias of STING agonists coated on microneedles for possible use in skin allergen immunotherapy. Molecular Pharmaceutics, 2018;15:5437-5443.(https://doi.org/10.1021/acs.molpharmaceut.8b00768) |
12. |
AK Shakya, CH Lee, HS Gill. Coated microneedle-based cutaneous immunotherapy prevents Der p1-induced airway allergy in mice. Journal of Allergy and Clinical Immunology, 2018;142:207-2011.e3. (https://doi.org/10.1016/j.jaci.2018.08.017) |
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13. |
AK Shakya*, KS Nandakumar. An update on smart biocatalysts for industrial and biomedical applications. Journal of the Royal Society Interface 2018;15:20180062. (*Corresponding author) (https://doi.org/10.1098/rsif.2018.0062) |
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14. |
AK Shakya*. KS Nandakumar. Antigen-specific tolerization and targeted delivery as therapeutic strategies for autoimmune diseases. Trends in Biotechnology, Cell Press 2018;36:7:686-699. (https://doi.org/10.1016/j.tibtech.2018.02.008) |
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2017
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15. |
AK Shakya, CH Lee, HS Gill. Coated microneedles for cutaneous preventive immunotherapy against airway allergies. Journal of Controlled Release, 2017;265:75-82. (https://doi.org/10.1016/j.jconrel.2017.08.012) |
16. |
K Shakya, U Kandalam. Three-dimensional macroporous Materials for Craniofacial Bone Tissue Engineering. British Journal of Oral & Maxillofacial Surgery, 2017;55:875-91. (https://doi.org/10.1016/j.bjoms.2017.09.007) |
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17. |
W Tao, B Hurst, AK Shakya, MdJ Uddin, RS Ingrole, HS Gill. Consensus M2e peptide conjugated to gold nanoparticles confers protection influenza A viruses. Antiviral Research, 2017;141:62-72. (https://doi.org/10.1016/j.antiviral.2017.01.021) |
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2016
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18. |
AK Shakya, W Tao, MYE Chowdhury, HS Gill. Mucosal vaccine delivery: Current state and a pediatric perspective. Journal of Controlled Release, 2016;240:394-413. (https://doi.org/10.1016/j.jconrel.2016.02.014) |
19. |
AK Shakya, A Kumar, R Holmdahl, KS Nandakumar. Macrophage-derived reactive oxygen species protect against autoimmune priming with a defined polymeric adjuvant. Immunology, 2016;147:125-32. (https://doi.org/10.1111/imm.12546) |
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2015
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20. |
AK Shakya*, A Srivastava, A Kumar. Polymeric cryogel-based boronate affinity chromatography for separation of Ribose Nucleic Acid. Wiley Current Protocols in Nucleic acid chemistry, 2015;63;10:1-10. (*Corresponding author) (https://doi.org/10.1002/0471142700.nc1016s63) |
21. |
AK Shakya, HS Gill. A comparative study of microneedle-based cutaneous immunization with other conventional routes to assess the feasibility of microneedles for allergy immunotherapy. Vaccine, 2015;33:4060-4. (https://doi.org/10.1016/j.vaccine.2015.06.042) |
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22. |
E Jain, A Damania, AK Shakya, SK Sarin, A Kumar. Fabrication of macroporous cryogels as potential hepatocyte carriers for bioartificial liver support. Colloids Surf B Biointerfaces, 2015;136:761-71. (https://doi.org/10.1016/j.colsurfb.2015.10.012) |
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2014
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23. |
AK Shakya, KS Nandakumar, A Kumar. Chemical cross-linking abrogates the adjuvant potential of natural polymers. Royal Society of Chemistry Advances, 2014;4:13817-21. (https://doi.org/10.1039/C4RA01331J) |
24. |
AK Shakya, R Holmdahl, KS Nandakumar, A Kumar. Polymeric cryogels are biocompatible and their biodegradation is independent of oxidative radicals. Journal of Biomedical Materials Research Part A, 2014;102:3409-18. (https://doi.org/10.1002/jbm.a.35013) |
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25. |
AK Shakya, KS Nandakumar. A synthetic polymer as an adjuvant in collagen-induced arthritis. Wiley Current protocols Mouse biology, 2014;4:1-12. (https://doi.org/10.1002/9780470942390.mo130226) |
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2013
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26. |
AK Shakya, R Holmdahl, KS Nandakumar, A Kumar. Characterization of chemically defined poly-N-isopropyl acrylamide-based copolymeric adjuvants. Vaccine, 2013;31:3519-27. (https://doi.org/10.1016/j.vaccine.2013.05.084) |
27. |
AK Shakya, KS Nandakumar. Polymeric adjuvants in studying autoimmune responses and vaccination against infectious diseases. Journal of the Royal Society Interface, 2013; 10:20120536. (https://doi.org/10.1098/rsif.2012.0536) |
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28. |
AK Shakya, A Kumar. Recent developments in atom transfer radical polymerization initiators. Journal of Bioscience and Biotechnology, 2013;2:1-11. (DOI:10.69085/jbb20131001) |
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2012
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29. |
AK Shakya, KS Nandakumar. Polymers as immunological adjuvants: An update on recent developments. Journal of Bioscience and Biotechnology, 2012;1:199-210. |
30. |
A Srivastava, AK Shakya$, A Kumar. Boronate affinity chromatography of cells and biomacromolecules using cryogels. Enzyme and Microbial Technology, 2012;51:373-81($Sharing first authorship). (https://doi.org/10.1016/j.enzmictec.2012.08.006) |
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2011
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31. |
AK Shakya, A Kumar, D Klaczkowska, KS Nandakumar. Collagen Type II and a Thermo-Responsive N-Isopropylacrylamide Induce Arthritis Independent of Toll-Like receptors. American Journal of Pathology, 2011;5:2490. (https://doi.org/10.1016/j.ajpath.2011.07.034) |
32. |
AK Shakya, A Kumar, and KS Nandakumar. A thermo-responsive polymeric [poly(N-isopropyl acrylamide)] adjuvant with collagen-induced autoimmunity and arthritis in mice. Journal of the Royal Society Interface 2011; 8:1748-59. (https://doi.org/10.1098/rsif.2011.0114) |
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2010
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33. |
AK Shakya, P Sharma, A Kumar. Synthesis and characterization of thermo-responsive poly(N-isopropyl acrylamide)-bovine liver catalase bioconjugate. Enzyme and Microbial Technology, 2010;47:277-82. (https://doi.org/10.1016/j.enzmictec.2010.07.018) |
34. |
AK Shakya, H Sami, A Srivastava, A Kumar. Stability of responsive polymer–protein bioconjugates. Progress in Polymer Science, 2010;35:459-86. (https://doi.org/10.1016/j.progpolymsci.2010.01.003) |
PATENTS
1. |
US11311617: Methods and Devices for the Treatment of Food Allergies, HS Gill, AK Shakya. Status: GRANTED. (Acquired by Moonlight Therapeutics, Inc.) |
2. |
US11510979B2: Pollen grains for treatment of airway and other allergies, HS Gill, AK Shakya. Status: GRANTED. |
3. |
US20240180848A: Targeting Junctional Epithelium in the Gingival Crevice for Immune Modulation, HS Gill, AK Shakya, Rohan SJ Ingrole. Status: FILED 2023. (Acquired by 3i Biotechnologies, Inc.) |
4. |
US63/136,743: Porcine Model for Allergic and Anaphylaxis reactions, HS Gill, AK Shakya, Brittany Backus, Lazar Nesovic. Status: FILED 2024. |
5. |
US Provisional 63/735, 726: Innovative Cryogel for Specific Autoantibodies Removal in Rheumatoid Arthritis Treatment. AK Shakya, FILED 2024. |
1. |
AK Shakya*, KS Nandakumar. Nano-size-based drug delivery systems for autoimmune diseases. In: Autoimmune disorders: Risk factors, pathogenesis, and treatments. Edited by KS Nandakumar. Nova Science publisher 2019 (ISBN:9781536160468). (*corresponding author). |
2. |
AK Shakya*, KS Nandakumar. Nanobiocatalysts for industrial applications. In: Characterization and biology of nanomaterials for drug delivery. Edited by S Mohapatra, S Ranjan, N Dasgupta, R Mishra, and S Thomas. Elsevier 2018. (ISBN:9780128140314) . (*corresponding author). |
3. |
AK Shakya*, KS Nandakumar. Biomaterials for induction and treatment of autoimmunity. In: Advances in biomaterials for biomedical applications. Edited by A Tripathi, and JS Melo. Springer Singapore 2017. (ISBN:9789811033278) (*corresponding author). |
4. |
AK Shakya, A Kumar. Biocompatibility of macroporous cryogel materials, In Supermacroporous cryogels: Biomedical and biotechnological applications. Edited by A Kumar, CRC Press 2015. (ISBN:9781482228816). |
5. |
AK Shakya*, H Madhyastha. Polymeric nanoparticles for vaccine delivery, In Integrating biologicallyinspired nanotechnology into medical practice. Edited by A Nanda, and MA Bhat, IGI Global 2015. (ISBN13:9781522506102) (*corresponding author). |
6. |
AK Shakya, KS Nandakumar. Stimuli-responsive polymers as adjuvants and carriers for antigen delivery. In: Responsive materials and methods. Edited by A Tiwari, and H Kobayashi. Scrivener Publishing Wiley 2013. (ISBN:9781118686225) (*corresponding author). |
7. |
AK Shakya*, KS Nandakumar. Nanomaterials applications in activation and suppression of immune response. In: Handbook of research diverse application of nanotechnology in biomedicine, chemistry, and engineering. Edited by S Soni, and A Salhotra. IGI Global 2014. (ISBN13:9781466663633) (*corresponding author). |
8. |
A Srivastava, AK Shakya, A Kumar. Particulate/cell separations using macroporous monolithic matrices. In: Advanced separations by specialized sorbents. Edited by ES Dragan, CRC Press 2014. (ISBN:9781482220551). |
9. |
AK Shakya*, KS Nandakumar. New generation vaccines: the need for safe and improved adjuvant. In: Vaccines and vaccine technology. Edited by JR Vasconcelos OMICS Group eBooks 2013, Foster City, USA. (ISBN:9781632780423) (*corresponding author). |
1. |
GKV Prabhu, AK Shakya, HS Gill. Controlling the Skins Delicate Immune Balance–from Microneedle Immunotherapy to Allergy Model Development. AICHE 2024 Annual Meeting, San Diego, CA, USA. |
2. |
CH Lee, AK Shakya, HS Gill. Elastin like polypeptides enhances mouse stem cells differentiation into cardiomyocyte-lime cells, Annual meeting ISSCR 2019, CA, USA. |
3. |
HS Gill, AK Shakya, CH Lee. Microneedles for cutaneous peanut allergen immunotherapy. AICHE 2019 Annual Meeting, Orlando, USA. |
4. |
AK Shakya, CH Lee and HS Gill. Coated microneedles mediated allergen-specific immunotherapy for the treatment of airway allergy in mice. Barrier function of mammalian skin, Gordon Research Seminar (GRS) 2019, Waterville Valley, NH, USA. |
5. |
AK Shakya, CH Lee, HS Gill. Microneedles for Allergen Immunotherapy: In Vivo Efficacy in Mouse Models of Airway Allergy. AICHE 2018, Annual Meeting, Pittsburgh, USA. |
6. |
AK Shakya, CH Lee, HS Gill. Microneedles-based cutaneous immunotherapy for allergy treatment. International Society of Vaccines 2016, Boston, USA. |
7. |
AK Shakya, CH Lee, HS Gill. Allergen-coated microneedles as a novel approach for preventive allergy immunotherapy. BMES 2016 Annual meeting, Minneapolis, USA. |
8. |
AK Shakya, HS Gill. Allergen-coated microneedles as a novel way for asthma preventive immunotherapy. Controlled Release Society 2015 Annual Meeting, Edinburg, Scotland. |
9. |
AK Shakya, HS Gill. Cutaneous allergen-specific immunotherapy using coated microneedles. Skin Vaccination Summit 2015, Switzerland. |
10. |
M Gatica, HS Gill, AK Shakya. Delivery of Ovalbumin through microneedles to prevent Ova allergy in mice. SACNASNational conference 2014, Los Angeles, USA. |
11. |
AK Shakya, A Kumar, KS Nandakumar. Poly-N-isopropylacrylamide as an adjuvant in collagen induced arthritis. 4th Indo-Australian conference Biomaterials, tissue engineering and drug delivery systems. BiTERM 2011, Gujarat, India. |
12. |
A Srivastava, AK Shakya, A Kumar. Boronate affinity chromatography of cells andbiomacromolecules using cryogels. 4th Indo-Australian conference “Biomaterials, tissue engineering and drug delivery systems. BiTERM 2011, Gujarat, India. |
13. |
AK Shakya, A Kumar, KS Nandakumar. Thermo-responsive poly-N-isopropylacrylamide as an adjuvant in experimental rheumatoid arthritis. Annual Meeting & Exposition Society for Biomaterials 2011, Orlando Florida, USA. |
14. |
A Srivastava, AK Shakya, A Kumar. Poly(N-vinylcaprolactam) based cryogel scaffold for tissue engineering applications: Synthesis & biophysical characterization. Annual meeting & Exposition, Society for Biomaterials 2010, Seattle Washington, USA. |
EcoBioMed Lab
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