Texas Tech University

Publications

PEER REVIEWED ARTICLES

2025

 

1.

Firdaus NHW, Mallick B, Nandakumar KS, Shakya AK*. Advantages of
using complement components in preventive and therapeutic vaccine strategies for infectious and non-infectious diseases. Journal of the Royal Society Interface 2025; 22:20250138. (*Corresponding author) (https://doi.org/10.1098/rsif.2025.0138)

2.

GKV Prabhu, AK Shakya, HS GIll. Microneedles Coated with Cow’s Milk Proteins: Immunogenicity, Stability, and Safety Assessment. Molecular Pharmaceutics 2025, 22, 6, 2858–2867. (https://doi.org/10.1021/acs.molpharmaceut.4c01136)

2024

3.

2023

 

4.

AK Shakya*, KS Nandakumar. Polymer Chemistry Defines Adjuvant Properties and Determines the Immune Response against the Antigen or Vaccine.Vaccines 2023, 11(9), 1395.  (*Corresponding author) (https://doi.org/10.3390/vaccines11091395)

5.

AK Shakya*, B Mallick, KS Nandakumar. A Perspective on Oral Immunotherapeutic Tools and Strategies for Autoimmune Disorders. Vaccines 2023, 11(6), 1031. (*Corresponding author) (https://doi.org/10.3390/vaccines11061031)

2022

 

 

6.

AK Shakya*. Functionalized cryogel monoliths for fast and selective separation of nucleic acids directly from the crude lysate. Biomedical Chromatography, 2022;36:e5333.  (*Corresponding author) (https://doi.org/10.1002/bmc.5333

7.

LD Nesovic, AK Shakya$, HS Gill. Treating allergies via skin-recent advances in cutaneous allergen immunotherapy. Advanced Drug Delivery Reviews, 2022, 114458. ($Sharing first authorship). (https://doi.org/10.1016/j.addr.2022.114458)

8.

JJ Landers, KW Janczak, AK Shakya, V Zarnitsyn, SR Patel, JRB Jr, HS Gill, JJ O’Konek. Targeted allergen-specific immunotherapy within the skin improves allergen delivery to induce desensitization to peanuts. Immunotherapy, 2022, 10.2217. (https://doi.org/10.2217/imt-2021-0206)

2020

9.

AK Shakya, CH Lee, HS Gill. Microneedles mediated allergen-specific immunotherapy for the treatment of airway allergy in mice. Molecular Pharmaceutics, 2020;17:3033-3042. (https://doi.org/10.1021/acs.molpharmaceut.0c00447)

2019

10.

AK Shakya, RS Ingrole, G Joshi, MdJ Uddin, S Anvari, CM Davis, HS Gill. Microneedles coated with peanut allergen enable desensitization of peanut-sensitized mice. Journal of Controlled Release, 2019;314:38-47. (https://doi.org/10.1016/j.jconrel.2019.09.022)

2018

 

 

 

11.

AK Shakya, CH Lee, MdJ Uddin, HS Gill. Assessment of Th1/Th2 bias of STING agonists coated on microneedles for possible use in skin allergen immunotherapy. Molecular Pharmaceutics, 2018;15:5437-5443.(https://doi.org/10.1021/acs.molpharmaceut.8b00768)

12.

AK Shakya, CH Lee, HS Gill. Coated microneedle-based cutaneous immunotherapy prevents Der p1-induced airway allergy in mice. Journal of Allergy and Clinical Immunology, 2018;142:207-2011.e3. (https://doi.org/10.1016/j.jaci.2018.08.017)

13.

AK Shakya*, KS Nandakumar. An update on smart biocatalysts for industrial and biomedical applications. Journal of the Royal Society Interface 2018;15:20180062.  (*Corresponding author) (https://doi.org/10.1098/rsif.2018.0062)

14.

AK Shakya*. KS Nandakumar. Antigen-specific tolerization and targeted delivery as therapeutic strategies for autoimmune diseases. Trends in Biotechnology, Cell Press 2018;36:7:686-699.  (https://doi.org/10.1016/j.tibtech.2018.02.008)

2017

 

 

15.

AK Shakya, CH Lee, HS Gill. Coated microneedles for cutaneous preventive immunotherapy against airway allergies. Journal of Controlled Release, 2017;265:75-82. (https://doi.org/10.1016/j.jconrel.2017.08.012)

16.

K Shakya, U Kandalam. Three-dimensional macroporous Materials for Craniofacial Bone Tissue Engineering. British Journal of Oral & Maxillofacial Surgery, 2017;55:875-91. (https://doi.org/10.1016/j.bjoms.2017.09.007)

17.

W Tao, B Hurst, AK Shakya, MdJ Uddin, RS Ingrole, HS Gill. Consensus M2e peptide conjugated to gold nanoparticles confers protection influenza A viruses. Antiviral Research, 2017;141:62-72. (https://doi.org/10.1016/j.antiviral.2017.01.021)

2016

 

18.

AK Shakya, W Tao, MYE Chowdhury, HS Gill. Mucosal vaccine delivery: Current state and a pediatric perspective. Journal of Controlled Release, 2016;240:394-413.  (https://doi.org/10.1016/j.jconrel.2016.02.014)

19.

AK Shakya, A Kumar, R Holmdahl, KS Nandakumar. Macrophage-derived reactive oxygen species protect against autoimmune priming with a defined polymeric adjuvant. Immunology, 2016;147:125-32.  (https://doi.org/10.1111/imm.12546)

2015

 

 

20.

AK Shakya*, A Srivastava, A Kumar. Polymeric cryogel-based boronate affinity chromatography for separation of Ribose Nucleic Acid. Wiley Current Protocols in Nucleic acid chemistry, 2015;63;10:1-10.  (*Corresponding author) (https://doi.org/10.1002/0471142700.nc1016s63)

21.

AK Shakya, HS Gill. A comparative study of microneedle-based cutaneous immunization with other conventional routes to assess the feasibility of microneedles for allergy immunotherapy. Vaccine, 2015;33:4060-4.  (https://doi.org/10.1016/j.vaccine.2015.06.042)

22.

E Jain, A Damania, AK Shakya, SK Sarin, A Kumar. Fabrication of macroporous cryogels as potential hepatocyte carriers for bioartificial liver support. Colloids Surf B Biointerfaces, 2015;136:761-71. (https://doi.org/10.1016/j.colsurfb.2015.10.012)

2014

 

 

23.

AK Shakya, KS Nandakumar, A Kumar. Chemical cross-linking abrogates the adjuvant potential of natural polymers. Royal Society of Chemistry Advances, 2014;4:13817-21.  (https://doi.org/10.1039/C4RA01331J)

24.

AK Shakya, R Holmdahl, KS Nandakumar, A Kumar. Polymeric cryogels are biocompatible and their biodegradation is independent of oxidative radicals. Journal of Biomedical Materials Research Part A, 2014;102:3409-18. (https://doi.org/10.1002/jbm.a.35013)

25.

AK Shakya, KS Nandakumar. A synthetic polymer as an adjuvant in collagen-induced arthritis. Wiley Current protocols Mouse biology, 2014;4:1-12. (https://doi.org/10.1002/9780470942390.mo130226)

2013

 

 

26.

AK Shakya, R Holmdahl, KS Nandakumar, A Kumar. Characterization of chemically defined poly-N-isopropyl acrylamide-based copolymeric adjuvants. Vaccine, 2013;31:3519-27. (https://doi.org/10.1016/j.vaccine.2013.05.084)

27.

AK Shakya, KS Nandakumar. Polymeric adjuvants in studying autoimmune responses and vaccination against infectious diseases. Journal of the Royal Society Interface, 2013; 10:20120536.  (https://doi.org/10.1098/rsif.2012.0536)

28.

AK Shakya, A Kumar. Recent developments in atom transfer radical polymerization initiators. Journal of Bioscience and Biotechnology, 2013;2:1-11. (DOI:10.69085/jbb20131001)

2012

 

29.

AK Shakya, KS Nandakumar. Polymers as immunological adjuvants: An update on recent developments. Journal of Bioscience and Biotechnology, 2012;1:199-210. 

30.

A Srivastava, AK Shakya$, A Kumar. Boronate affinity chromatography of cells and biomacromolecules using cryogels. Enzyme and Microbial Technology, 2012;51:373-81($Sharing first authorship). (https://doi.org/10.1016/j.enzmictec.2012.08.006)

2011

 

31.

AK Shakya, A Kumar, D Klaczkowska, KS Nandakumar. Collagen Type II and a Thermo-Responsive N-Isopropylacrylamide Induce Arthritis Independent of Toll-Like receptors. American Journal of Pathology, 2011;5:2490. (https://doi.org/10.1016/j.ajpath.2011.07.034

32.

AK Shakya, A Kumar, and KS Nandakumar. A thermo-responsive polymeric [poly(N-isopropyl acrylamide)] adjuvant with collagen-induced autoimmunity and arthritis in mice. Journal of the Royal Society Interface 2011; 8:1748-59.  (https://doi.org/10.1098/rsif.2011.0114)

2010

 

33.

AK Shakya, P Sharma, A Kumar. Synthesis and characterization of thermo-responsive poly(N-isopropyl acrylamide)-bovine liver catalase bioconjugate. Enzyme and Microbial Technology, 2010;47:277-82.  (https://doi.org/10.1016/j.enzmictec.2010.07.018)

34.

AK Shakya, H Sami, A Srivastava, A Kumar. Stability of responsive polymer–protein bioconjugates. Progress in Polymer Science, 2010;35:459-86. (https://doi.org/10.1016/j.progpolymsci.2010.01.003)

PATENTS

1.

US11311617: Methods and Devices for the Treatment of Food Allergies, HS Gill, AK Shakya. Status: GRANTED. (Acquired by Moonlight Therapeutics, Inc.)

2.

US11510979B2: Pollen grains for treatment of airway and other allergies, HS Gill, AK Shakya. Status: GRANTED.

3.

US20240180848A: Targeting Junctional Epithelium in the Gingival Crevice for Immune Modulation, HS Gill, AK Shakya, Rohan SJ Ingrole. Status: FILED 2023. (Acquired by 3i Biotechnologies, Inc.)

4.

US63/136,743: Porcine Model for Allergic and Anaphylaxis reactions, HS Gill, AK Shakya, Brittany Backus, Lazar Nesovic. Status: FILED 2024.

5.

US Provisional 63/735, 726: Innovative Cryogel for Specific Autoantibodies Removal in Rheumatoid Arthritis Treatment. AK Shakya, FILED 2024.

BOOK CHAPTERS

1.

AK Shakya*, KS Nandakumar. Nano-size-based drug delivery systems for autoimmune diseases. In: Autoimmune disorders: Risk factors, pathogenesis, and treatments. Edited by KS Nandakumar. Nova Science publisher 2019 (ISBN:9781536160468). (*corresponding author).

2.

AK Shakya*, KS Nandakumar. Nanobiocatalysts for industrial applications. In: Characterization and biology of nanomaterials for drug delivery. Edited by S Mohapatra, S Ranjan, N Dasgupta, R Mishra, and S Thomas. Elsevier 2018. (ISBN:9780128140314) . (*corresponding author).

3.

AK Shakya*, KS Nandakumar. Biomaterials for induction and treatment of autoimmunity. In: Advances in biomaterials for biomedical applications. Edited by A Tripathi, and JS Melo. Springer Singapore 2017. (ISBN:9789811033278) (*corresponding author).  

4.

AK Shakya, A Kumar. Biocompatibility of macroporous cryogel materials, In Supermacroporous cryogels: Biomedical and biotechnological applications. Edited by A Kumar, CRC Press 2015. (ISBN:9781482228816).

5.

AK Shakya*, H Madhyastha. Polymeric nanoparticles for vaccine delivery, In Integrating biologicallyinspired nanotechnology into medical practice. Edited by A Nanda, and MA Bhat, IGI Global 2015. (ISBN13:9781522506102) (*corresponding author). 

6.

AK Shakya, KS Nandakumar. Stimuli-responsive polymers as adjuvants and carriers for antigen delivery. In: Responsive materials and methods. Edited by A Tiwari, and H Kobayashi. Scrivener Publishing Wiley 2013. (ISBN:9781118686225) (*corresponding author). 

7.

AK Shakya*, KS Nandakumar. Nanomaterials applications in activation and suppression of immune response. In: Handbook of research diverse application of nanotechnology in biomedicine, chemistry, and engineering. Edited by S Soni, and A Salhotra. IGI Global 2014. (ISBN13:9781466663633) (*corresponding author). 

8.

A Srivastava, AK Shakya, A Kumar. Particulate/cell separations using macroporous monolithic matrices. In: Advanced separations by specialized sorbents. Edited by ES Dragan, CRC Press 2014. (ISBN:9781482220551).

9.

AK Shakya*, KS Nandakumar. New generation vaccines: the need for safe and improved adjuvant. In: Vaccines and vaccine technology. Edited by JR Vasconcelos OMICS Group eBooks 2013, Foster City, USA. (ISBN:9781632780423) (*corresponding author). 

CONFERENCE PROCEEDINGS

1.

GKV Prabhu, AK Shakya, HS Gill. Controlling the Skin’s Delicate Immune Balance–from Microneedle Immunotherapy to Allergy Model Development. AICHE 2024 Annual Meeting, San Diego, CA, USA.

2.

CH Lee, AK Shakya, HS Gill. Elastin like polypeptides enhances mouse stem cells differentiation into cardiomyocyte-lime cells, Annual meeting ISSCR 2019, CA, USA.

3.

HS Gill, AK Shakya, CH Lee. Microneedles for cutaneous peanut allergen immunotherapy. AICHE 2019 Annual Meeting, Orlando, USA.

4.

AK Shakya, CH Lee and HS Gill. Coated microneedles mediated allergen-specific immunotherapy for the treatment of airway allergy in mice. Barrier function of mammalian skin, Gordon Research Seminar (GRS) 2019, Waterville Valley, NH, USA.

5.

AK Shakya, CH Lee, HS Gill. Microneedles for Allergen Immunotherapy: In Vivo Efficacy in Mouse Models of Airway Allergy. AICHE 2018, Annual Meeting, Pittsburgh, USA.

6.

AK Shakya, CH Lee, HS Gill. Microneedles-based cutaneous immunotherapy for allergy treatment. International Society of Vaccines 2016, Boston, USA.

7.

AK Shakya, CH Lee, HS Gill. Allergen-coated microneedles as a novel approach for preventive allergy immunotherapy. BMES 2016 Annual meeting, Minneapolis, USA.

8.

AK Shakya, HS Gill. Allergen-coated microneedles as a novel way for asthma preventive immunotherapy. Controlled Release Society 2015 Annual Meeting, Edinburg, Scotland.

9.

AK Shakya, HS Gill. Cutaneous allergen-specific immunotherapy using coated microneedles. Skin Vaccination Summit 2015, Switzerland.

10.

M Gatica, HS Gill, AK Shakya. Delivery of Ovalbumin through microneedles to prevent Ova allergy in mice. SACNASNational conference 2014, Los Angeles, USA.

11.

AK Shakya, A Kumar, KS Nandakumar. Poly-N-isopropylacrylamide as an adjuvant in collagen induced arthritis. 4th Indo-Australian conference Biomaterials, tissue engineering and drug delivery systems. BiTERM 2011, Gujarat, India.

12.

A Srivastava, AK Shakya, A Kumar. Boronate affinity chromatography of cells andbiomacromolecules using cryogels. 4th Indo-Australian conference “Biomaterials, tissue engineering and drug delivery systems. BiTERM 2011, Gujarat, India.

13.

AK Shakya, A Kumar, KS Nandakumar. Thermo-responsive poly-N-isopropylacrylamide as an adjuvant in experimental rheumatoid arthritis. Annual Meeting & Exposition Society for Biomaterials 2011, Orlando Florida, USA.

14.

A Srivastava, AK Shakya, A Kumar. Poly(N-vinylcaprolactam) based cryogel scaffold for tissue engineering applications: Synthesis & biophysical characterization. Annual meeting & Exposition, Society for Biomaterials 2010, Seattle Washington, USA.