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Publications

PEER-REVIEWED ARTICLES
 
 
2026
40.
 A Hesaneh, NHW Firdaus, R Joshi, AK Shakya*, W Li*. Allergen-Functionalized Microfluidic Immunoadsorption Platform for Selective Depletion of Peanut-specific Antibodies from Whole Blood. Journal of Polymer Science 2026 (DOI: 10.1002/pola.70362). 
39.
 A Mehranfar, AK Shakya, R Faller. Gold Nanoparticle–Based Systems for Targeting the Ara~h2 Allergen: A Molecular Modeling Approach. Computational and Structural Biotechnology Journal 2026, 35(3). (https://spj.science.org/doi/10.34133/csbj.0088 ) 
38.
 M Kumar, S Nalla, JN Tripathy, AK Shakya. Bioengineering Interventions to Enhance the Capacity of the Gut Microbiota in Controlling Food Allergies. Life 2026, 16(3), 433. (https://doi.org/10.3390/life16030433)
 
 
 
 
2025
 
37.
 A Bhattu, N Khatiwada, M Kumar, NHW Firdaus, Z Hong, AK Shakya. Selective Binding of Autoantibodies using Polymeric Gel for Management of Autoimmune Arthritis. Advanced Therapeutics 2025, e00135. (https://doi.org/10.1002/adtp.202500135)
36.
 NHW Firdaus, B Mallick, KS Nandakumar, AK Shakya. Advantages of
using complement components in preventive and therapeutic vaccine strategies for infectious and non-infectious diseases. Journal of the Royal Society Interface 2025; 22:20250138. (https://doi.org/10.1098/rsif.2025.0138)
35.
 BC Vaddaram, AK Shakya, BR Zadeh, DM Lopez, J Wagner, T Parco, U Kandalam. The Therapeutic Scope of Orofacial Mesenchymal Stem Cells. Bioengineering 2025, 12(9), 970. (https://doi.org/10.3390/bioengineering12090970).
34.
Rohan SJ Ingrole, AK Shakya, G Joshi, CH Lee, LD Nesovic, RW Compans, HS Gill. Floss-based vaccination targets the gingival sulcus for mucosal and systemic immunization. Nature Biomedical Engineeering 2025. (https://doi.org/10.1038/s41551-025-01451-3).
33.
GKV Prabhu, AK Shakya, HS GIll. Microneedles Coated with Cow’s Milk Proteins: Immunogenicity, Stability, and Safety Assessment. Molecular Pharmaceutics 2025, 22, 6, 2858–2867. (https://doi.org/10.1021/acs.molpharmaceut.4c01136)
2024
32.
2023
 
31.
AK Shakya, KS Nandakumar. Polymer Chemistry Defines Adjuvant Properties and Determines the Immune Response against the Antigen or Vaccine.Vaccines 2023, 11(9), 1395. (https://doi.org/10.3390/vaccines11091395)
30.
AK Shakya, B Mallick, KS Nandakumar. A Perspective on Oral Immunotherapeutic Tools and Strategies for Autoimmune Disorders. Vaccines 2023, 11(6), 1031.(https://doi.org/10.3390/vaccines11061031)
2022
 
 
29.
AK Shakya. Functionalized cryogel monoliths for fast and selective separation of nucleic acids directly from the crude lysate. Biomedical Chromatography, 2022;36:e5333.  (https://doi.org/10.1002/bmc.5333) 
28.
LD Nesovic, AK Shakya$, HS Gill. Treating allergies via skin-recent advances in cutaneous allergen immunotherapy. Advanced Drug Delivery Reviews, 2022, 114458.  (https://doi.org/10.1016/j.addr.2022.114458)
27.
JJ Landers, KW Janczak, AK Shakya, V Zarnitsyn, SR Patel, JRB Jr, HS Gill, JJ O’Konek. Targeted allergen-specific immunotherapy within the skin improves allergen delivery to induce desensitization to peanuts. Immunotherapy, 2022, 10.2217. (https://doi.org/10.2217/imt-2021-0206)
2020
26.
AK Shakya, CH Lee, HS Gill. Microneedles mediated allergen-specific immunotherapy for the treatment of airway allergy in mice. Molecular Pharmaceutics, 2020;17:3033-3042. (https://doi.org/10.1021/acs.molpharmaceut.0c00447)
2019
25.
AK Shakya, RS Ingrole, G Joshi, MdJ Uddin, S Anvari, CM Davis, HS Gill. Microneedles coated with peanut allergen enable desensitization of peanut-sensitized mice. Journal of Controlled Release, 2019;314:38-47. (https://doi.org/10.1016/j.jconrel.2019.09.022)
2018
 
 
 
24.
AK Shakya, CH Lee, MdJ Uddin, HS Gill. Assessment of Th1/Th2 bias of STING agonists coated on microneedles for possible use in skin allergen immunotherapy. Molecular Pharmaceutics, 2018;15:5437-5443.(https://doi.org/10.1021/acs.molpharmaceut.8b00768)
23.
AK Shakya, CH Lee, HS Gill. Coated microneedle-based cutaneous immunotherapy prevents Der p1-induced airway allergy in mice. Journal of Allergy and Clinical Immunology, 2018;142:207-2011.e3. (https://doi.org/10.1016/j.jaci.2018.08.017)
22.
AK Shakya*, KS Nandakumar. An update on smart biocatalysts for industrial and biomedical applications. Journal of the Royal Society Interface 2018;15:20180062.  (https://doi.org/10.1098/rsif.2018.0062)
21.
AK Shakya*. KS Nandakumar. Antigen-specific tolerization and targeted delivery as therapeutic strategies for autoimmune diseases. Trends in Biotechnology, Cell Press 2018;36:7:686-699.  (https://doi.org/10.1016/j.tibtech.2018.02.008)
2017
 
 
20.
AK Shakya, CH Lee, HS Gill. Coated microneedles for cutaneous preventive immunotherapy against airway allergies. Journal of Controlled Release, 2017;265:75-82. (https://doi.org/10.1016/j.jconrel.2017.08.012)
19.
AK Shakya, U Kandalam. Three-dimensional macroporous Materials for Craniofacial Bone Tissue Engineering. British Journal of Oral & Maxillofacial Surgery, 2017;55:875-91. (https://doi.org/10.1016/j.bjoms.2017.09.007)
18.
W Tao, B Hurst, AK Shakya, MdJ Uddin, RS Ingrole, HS Gill. Consensus M2e peptide conjugated to gold nanoparticles confers protection influenza A viruses. Antiviral Research, 2017;141:62-72. (https://doi.org/10.1016/j.antiviral.2017.01.021)
2016
 
17.
AK Shakya, W Tao, MYE Chowdhury, HS Gill. Mucosal vaccine delivery: Current state and a pediatric perspective. Journal of Controlled Release, 2016;240:394-413.  (https://doi.org/10.1016/j.jconrel.2016.02.014)
16.
AK Shakya, A Kumar, R Holmdahl, KS Nandakumar. Macrophage-derived reactive oxygen species protect against autoimmune priming with a defined polymeric adjuvant. Immunology, 2016;147:125-32.  (https://doi.org/10.1111/imm.12546)
2015
 
 
15.
AK Shakya*, A Srivastava, A Kumar. Polymeric cryogel-based boronate affinity chromatography for separation of Ribose Nucleic Acid. Wiley Current Protocols in Nucleic Acid Chemistry, 2015;63;10:1-10.  (https://doi.org/10.1002/0471142700.nc1016s63)
14.
AK Shakya, HS Gill. A comparative study of microneedle-based cutaneous immunization with other conventional routes to assess the feasibility of microneedles for allergy immunotherapy. Vaccine, 2015;33:4060-4.  (https://doi.org/10.1016/j.vaccine.2015.06.042)
13.
E Jain, A Damania, AK Shakya, SK Sarin, A Kumar. Fabrication of macroporous cryogels as potential hepatocyte carriers for bioartificial liver support. Colloids Surf B Biointerfaces, 2015;136:761-71. (https://doi.org/10.1016/j.colsurfb.2015.10.012)
2014
 
 
12.
AK Shakya, KS Nandakumar, A Kumar. Chemical cross-linking abrogates the adjuvant potential of natural polymers. Royal Society of Chemistry Advances, 2014;4:13817-21.  (https://doi.org/10.1039/C4RA01331J)
11.
AK Shakya, R Holmdahl, KS Nandakumar, A Kumar. Polymeric cryogels are biocompatible and their biodegradation is independent of oxidative radicals. Journal of Biomedical Materials Research Part A, 2014;102:3409-18. (https://doi.org/10.1002/jbm.a.35013)
10.
AK Shakya, KS Nandakumar. A synthetic polymer as an adjuvant in collagen-induced arthritis. Wiley Current protocols Mouse biology, 2014;4:1-12. (https://doi.org/10.1002/9780470942390.mo130226)
2013
 
 
9.
AK Shakya, R Holmdahl, KS Nandakumar, A Kumar. Characterization of chemically defined poly-N-isopropyl acrylamide-based copolymeric adjuvants. Vaccine, 2013;31:3519-27. (https://doi.org/10.1016/j.vaccine.2013.05.084)
8.
AK Shakya, KS Nandakumar. Polymeric adjuvants in studying autoimmune responses and vaccination against infectious diseases. Journal of the Royal Society Interface, 2013; 10:20120536.  (https://doi.org/10.1098/rsif.2012.0536)
7.
AK Shakya, A Kumar. Recent developments in atom transfer radical polymerization initiators. Journal of Bioscience and Biotechnology, 2013;2:1-11. (DOI:10.69085/jbb20131001)
2012
 
6.
AK Shakya, KS Nandakumar. Polymers as immunological adjuvants: An update on recent developments. Journal of Bioscience and Biotechnology, 2012;1:199-210.  (DOI: 10.69085/jbb20123199)
5.
A Srivastava, AK Shakya, A Kumar. Boronate affinity chromatography of cells and biomacromolecules using cryogels. Enzyme and Microbial Technology, 2012;51:373-81. (https://doi.org/10.1016/j.enzmictec.2012.08.006)
2011
 
4.
AK Shakya, A Kumar, D Klaczkowska, KS Nandakumar. Collagen Type II and a Thermo-Responsive N-Isopropylacrylamide Induce Arthritis Independent of Toll-Like receptors. American Journal of Pathology, 2011;5:2490. (https://doi.org/10.1016/j.ajpath.2011.07.034) 
3.
AK Shakya, A Kumar, and KS Nandakumar. A thermo-responsive polymeric [poly(N-isopropyl acrylamide)] adjuvant with collagen-induced autoimmunity and arthritis in mice. Journal of the Royal Society Interface 2011; 8:1748-59.  (https://doi.org/10.1098/rsif.2011.0114)
2010
 
2.
AK Shakya, P Sharma, A Kumar. Synthesis and characterization of thermo-responsive poly(N-isopropyl acrylamide)-bovine liver catalase bioconjugate. Enzyme and Microbial Technology, 2010;47:277-82.  (https://doi.org/10.1016/j.enzmictec.2010.07.018)
1.
AK Shakya, H Sami, A Srivastava, A Kumar. Stability of responsive polymer–protein bioconjugates. Progress in Polymer Science, 2010;35:459-86. (https://doi.org/10.1016/j.progpolymsci.2010.01.003)
CONFERENCE PROCEEDINGS
2025 16. AK Shakya. Affinity of Poly-N-Isopropylacrylamide-Collagen Type II Gel Column for Selective Binding of Autoantibodies for Management of Rheumatoid Arthritis. AICHE 2025 Annual Meeting, Boston, MA, USA.(https://aiche.confex.com/aiche/2025/meetingapp.cgi/Paper/707794)
15.  A Mehranfar, AK Shakya, R Faller. Targeting Peanut Allergens: A Molecular Approach from Epitope Prediction to Small Molecule Drug Design. AICHE 2025 Annual Meeting, Boston, MA, USA. (https://aiche.confex.com/aiche/2025/meetingapp.cgi/Paper/721206)
2024 14. GKV Prabhu, AK Shakya, HS Gill. Controlling the Skin’s Delicate Immune Balance–from Microneedle Immunotherapy to Allergy Model Development. AICHE 2024 Annual Meeting, San Diego, CA, USA. (https://aiche.confex.com/aiche/2024/meetingapp.cgi/Paper/688669)
2019

 13. CH Lee, AK Shakya, HS Gill. Elastin like polypeptides enhances mouse stem cells differentiation into cardiomyocyte-lime cells, Annual meeting ISSCR 2019, CA, USA.
12. HS Gill, AK Shakya, CH Lee. Microneedles for cutaneous peanut allergen immunotherapy. AICHE 2019 Annual Meeting, Orlando, USA. (https://proceedings.aiche.org/conferences/aiche-annual-meeting/2019/proceeding/paper/685h-microneedles-cutaneous-peanut-allergen-immunotherapy)
11. AK Shakya, CH Lee and HS Gill. Coated microneedles mediated allergen-specific immunotherapy for the treatment of airway allergy in mice. Barrier function of mammalian skin, Gordon Research Seminar (GRS) 2019, Waterville Valley, NH, USA.
2018 10. AK Shakya, CH Lee, HS Gill. Microneedles for Allergen Immunotherapy: In Vivo Efficacy in Mouse Models of Airway Allergy. AICHE 2018, Annual Meeting, Pittsburgh, USA. (https://proceedings.aiche.org/conferences/aiche-annual-meeting/2018/proceeding/paper/559b-microneedles-allergen-immunotherapy-vivo-efficacy-mouse-models-airway-allergy)
2016 9. AK Shakya, CH Lee, HS Gill. Microneedles-based cutaneous immunotherapy for allergy treatment. International Society of Vaccines 2016, Boston, USA.
8. AK Shakya, CH Lee, HS Gill. Allergen-coated microneedles as a novel approach for preventive allergy immunotherapy. BMES 2016 Annual meeting, Minneapolis, USA.
2015 7. AK Shakya, HS Gill. Allergen-coated microneedles as a novel way for asthma preventive immunotherapy. Controlled Release Society 2015 Annual Meeting, Edinburg, Scotland.
6. AK Shakya, HS Gill. Cutaneous allergen-specific immunotherapy using coated microneedles. Skin Vaccination Summit 2015, Switzerland.
2014 5. M Gatica, HS Gill, AK Shakya. Delivery of Ovalbumin through microneedles to prevent Ova allergy in mice. SACNASNational conference 2014, Los Angeles, USA.
2011

 4. AK Shakya, A Kumar, KS Nandakumar. Poly-N-isopropylacrylamide as an adjuvant in collagen induced arthritis. 4th Indo-Australian conference Biomaterials, tissue engineering and drug delivery systems. BiTERM 2011, Gujarat, India.
3. A Srivastava, AK Shakya, A Kumar. Boronate affinity chromatography of cells andbiomacromolecules using cryogels. 4th Indo-Australian conference “Biomaterials, tissue engineering and drug delivery systems. BiTERM 2011, Gujarat, India.
2. AK Shakya, A Kumar, KS Nandakumar. Thermo-responsive poly-N-isopropylacrylamide as an adjuvant in experimental rheumatoid arthritis. Annual Meeting & Exposition Society for Biomaterials 2011, Orlando Florida, USA.
2010 1. A Srivastava, AK Shakya, A Kumar. Poly(N-vinylcaprolactam) based cryogel scaffold for tissue engineering applications: Synthesis & biophysical characterization. Annual meeting & Exposition, Society for Biomaterials 2010, Seattle Washington, USA. 

Shakya Lab

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