Lewis Irving Held
Email: See TTU Directory
Phone: (806) 834-3283
- Ph.D., Molecular Biology, University of California Berkeley, 1977.
- B.S., Life Sciences, Massachusetts Institute of Technology, 1973.
- President's Excellence in Teaching Medal, TTU, 1995.
- Professing Excellence Award, University Student Housing, 2010.
- Professing Excellence Award, University Student Housing, 2016.
- 2nd Place Medal, TTU University-wide Book Competition, 2004.
- 2nd Place Medal, TTU University-wide Book Competition, 2011.
- 3rd Place Medal, TTU University-wide Book Competition, 2016.
Wall Street Journal interviews Prof. Held about Darwinian evolution
Cambridge Univ. Press interviews Prof. Held about Darwin's legacy
Daily Toreador interviews Prof. Held about life & a fly joint mutation
For student use only (BIOL 3302): StemCells1; StemCells2; Organoids1; Organoids2; Organoids3; RegrowArms?; MorphogenGradients; MovieTranscript.
For student use only (BIOL 4110): EvoDevoVideo1; EvoDevoVideo2; EvoDevoSlideshow; EvoDevo1; EvoDevo2; EvoDevo3; EvoDevo4; FlyArt.
For student use only (BIOL 1403): EvolutionSlideshow.
Flies ≈ humans!: OrganSystems; Vision; WhyFlies?Video1(Basic); WhyFlies?Video2(Advanced); WhyFlies1?; WhyFlies2?; WhyFlies3?; WhyFlies4?; WhyFlies5?; WhyFlies6?; WhyFlies7?; WhyFlies8?; WhyFlies9?; WhyFlies10?; WhyFlies11?; WhyFlies12?; WhyFlies13?; WhyFlies14?; FlyWorld1; Links-to-Literature.
Wonderlands of Fly Genes: InteractiveFly; FunWithFlies; Twitter; Nobel Prizes.
Nobel Prize to 3 Fly Guys (2017): Awarded for basic research on circadian rhythms in fruit flies to Jeff Hall, Michael Rosbash, and Michael Young.
Whimsical musical parodies: Evo-devo (lyrics); Biochemistry; Science appreciation; catalog of Tim Blais videos.
Research in my lab has focused on pattern formation: how do cells construct anatomy? The model system we have used is the leg of the fruit fly and its exquisitely intricate patterns of bristles. Over the years we have probed how various signaling pathways (TGF-beta, Wnt, and EGFR) establish the axes, boundaries, and coordinates of the leg landscape. Recently we solved (at least partially) an intriguing riddle in evolutionary developmental (evo-devo) biology: how did the 1st pair of legs become different from the 2nd pair in terms of its sex comb (on the male tarsus) and its transverse rows (on the tibiae of both sexes)? We found that a master gene in the Hox complex (called Scr ) causes transverse row bristles to be yellow and bractless by direct intervention, whereas its other effects appear to be mediated indirectly by as-yet unidentified circuits. Currently we are using RNAi to probe the role of cell movements (as controlled by Rac & Rho) in fine-tuning bristle alignments, which are astoundingly regular in transverse rows & elsewhere.
Held, L. I., Jr. (2017) Deep Homology? Uncanny Similarities of Humans and Flies Uncovered by Evo-Devo. Cambridge University Press. 272 pp. [Comparison of the genomic "operating systems" of humans and flies in terms of how the very same algorithms can build wildly different anatomies.] This book is the third volume in a trilogy of books about evo-devo: Quirks = Vol.1; Snake = Vol.2; DH = Vol.3. book review 1, book review 2.
Held, L. I., Jr. (2014) How the Snake Lost its Legs: Curious Tales from the Frontier of Evo-devo. Cambridge University Press. 285 pp. [A factual homage to Rudyard Kipling's fanciful Just So Stories . How the leopard actually got its spots, the zebra its stripes, the camel its hump, etc., from a modern genetic perspective.] book review 1 , book review 2 , book review 3, book review 4, book review 5.
- Held, L. I., Jr., Billingsley, S. A., Muñoz, J. O. (2014) Disabling Cdc42 disrupts bristle patterning. Dros. Info. Serv. 97 , 45-51. [Filopodia may mediate bristle-cell movements.]
- Held, L. I., Jr. (2013) Rethinking butterfly eyespots. Evol. Biol. 40 , 158-168. [A new evo-devo hypothesis for how butterflies got their spots.]
- Held, L. I., Jr. (2011) When does the spiny legs1 allele of the prickle gene cause extra joints? Dros. Info. Serv. 94 , 47-52. [Probing the etiology of a bizarre syndrome.]
- Held, L. I., Jr. (2010) How does Scr cause first legs to deviate from second legs? Dros. Info. Serv. 93 , 132-146. [A "Sherlock Holmes" study of old clues left by a Master Gene.]
- Held, L. I., Jr. (2010) The evolutionary geometry of human anatomy: Discovering our inner fly. Evol. Anthropol. 19 , 227-235. [Applying insights from flies to the human genome.]
- Held, L. I., Jr. (2010) The evo-devo puzzle of human hair patterning. Evol. Biol. 37 , 113-122. [Reflections on why humans are the only "naked" apes and why men go bald.]
- Held, L. I., Jr. (2009) 101 Unsolved Puzzles in Evo-Devo . Ancillary Workbook (Problem Sets) for Quirks of Human Anatomy . [Mental exercises for those curious about oddities.]
- Held, L. I., Jr. (2005) Suppressing apoptosis fails to cure "extra-joint syndrome" or to stop sex-comb rotation. Drosophila Info. Serv. 88 , 9-10. [The syndrome causes double joints.]
- Held, L. I., Jr., Grimson, M. J., Du, Z. (2004) Proving an old prediction: The sex comb rotates at 16-24 hrs after pupariation. Drosophila Info. Serv. 87 , 76-78. [A rare proof.]
- Held, L. I., Jr. (2003) Tetraploid male mosaics induced by pressure. Drosophila Info. Serv. 86 , 50-53. [The cells of tetraploids are twice the volume of diploids & look a bit odd.]
Held, L. I., Jr. (2002) Imaginal Discs: The Genetic and Cellular Logic of Pattern Formation . Cambridge University Press. 460 pp. [History of a century of fly genetics, which has succeeded in deciphering the process of metamorphosis that converts discs into legs, wings, eyes, etc.] book review 1, book review 2.
- Held, L. I., Jr. (2002) Bristles induce bracts via the EGFR pathway on Drosophila legs. Mechanisms of Development 117 , 225-234. [The smallest known inductive interaction.]
- Held, L. I., Jr. (2002) Why should transverse rows need the EGFR pathway to align properly on Drosophila legs? Drosophila Info. Serv.85, 17-19. [How bristle cells align into surprisingly straight rows.]
- Held, L. I., Jr., Heup, M.A. (1996) Genetic mosaic analysis of decapentaplegic and wingless gene function in the Drosophila leg. Development, Genes and Evolution 206 , 180-194. [A critical piece in the puzzle of how genes generate geometry in fly legs.]
- Held, L. I., Jr. (1995) Axes, boundaries, and coordinates: the ABCs of fly leg development. BioEssays 17 , 721-732. [Overview of geometry of leg development.]
- Held, L. I., Jr., Heup, M.A., Sappington, J.M., and Peters, S.D. (1994) Interactions of decapentaplegic , wingless , and Distal-less in the Drosophila leg. Rouxs Arch. Dev. Biol. 203 , 310-319. [Genetic basis for how the fly leg establishes a coordinate system.]
Held, L. I., Jr. (1992) Models for Embryonic Periodicity. Karger. 119 pp. [Historical survey of theories for how embryos make spatially periodic patterns, such as fingers, phalanges, and fingerprints, tree branches, flower petals, body segments, vertebrae, teeth, etc. An homage to William Bateson's classic monograph Materials for the Study of Variation published a century earlier.] book review 1.