Mark A. Sheridan

Research Interests

I am interested in the coordinate regulation of growth, development, and metabolism of vertebrate animals by hormones and environmental factors .  Current projects include the following:

Selected Publications

• Sheridan, M. A.  1988.  Lipid dynamics in fish: Aspects of absorption, deposition, transport and mobilization.  Comp. Biochem. Physiol. 90B: 679 690.
• Sheridan M.A. 1989.  Alterations in lipid metabolism accompanying smoltification and seawater adaptation of salmonid fish.  Aquaculture 82: 191-203. 
• Sheridan, M.A.  1994.  Regulation of lipid metabolism in poikilothermic vertebrates.  Comp. Biochem. Physiol. 107B:495-508.
• Sheridan, M.A. and Kao, Y.-H.  1998.  Regulation of metamorphosis-associated changes in lipid metabolism of selected vertebrates.  Am. Zool. 38: 350-368.
• Sheridan, M.A., Kittilson, J.D., and Slagter, B.J.  2000.  Structure-function relationships of the signaling system for the somatostatin peptide hormone family.  Am. Zool. 40:269-286.
• Nelson, L.E. and Sheridan, M.A.  2005.  Regulation of somatostatins and their receptors in fish.  Gen. Comp. Endocrinol. 142: 117-133.
• Klein, S.E. and Sheridan, M.A.  2008.  Somatostatin signaling and the regulation of growth and metabolism in fish.  Mol. Cell. Endocrinol. 286: 148-154.
• Reindl, K. Kittilson, J., Bergan, H., and Sheridan, M.A. 2011.  Growth hormone-stimulated insulin-like growth factor-1 expression in rainbow trout (Oncorhynchus mykiss) hepatocytes is mediated by ERK, PI3K-AKT, and JAK-STAT.  Am. J. Physiol. 301: R236-R243.
• Norbeck, L.A. and Sheridan, M.A. 2011. An in vitro model for evaluating the peripheral regulation of growth in fish: Effects of 17β-estradiol and testosterone on the expression of growth hormone receptors, insulin-like growth factors, and insulin-like growth factor type 1 receptors in rainbow trout (Oncorhynchus mykiss).  Gen. Comp. Endocrinol. 173: 270-280.
• Caruso, M.A. and Sheridan, M.A. 2011. New insights into the signaling system and function of insulin in fish.  Gen. Comp. Endocrinol. 173: 227-247.
• Kittilson, J.D., Slagter, B.A., Martin, L., and Sheridan, M.A. 2011.  Isolation, characterization, and distribution of somatostatin receptor subtype 2 (SSTR2) mRNA in rainbow trout (Oncorhynchus mykiss), and regulation of its expression by glucose.  Comp. Biochem. Physiol.  160A: 237-247.
• Kittilson, J., Jones, E. and Sheridan, M.A. 2011.  The ERK, PI3K/Akt, and JAK-STAT pathways are differentially activated by the two growth hormone receptor subtypes of a teleost fish (Oncorhynchus mykiss).  Front. Endocrinol. 2(30)1-7.
• Caruso, M.A. and Sheridan, M.A. 2012.  The expression of insulin and insulin receptor mRNAs is regulated by nutritional state and glucose in rainbow trout (Oncorhynchus mykiss).  Gen. Comp. Endocrinol. 175: 321-328.
• Bergan, H.E., Kittilson, J.D., and Sheridan, M.A. 2012.  Nutrition-regulated lipolysis in rainbow trout (Oncorhynchus mykiss) is associated with alterations in the ERK, PI3K-Akt, JAK-STAT, and PKC signaling pathways.  Gen. Comp. Endocrinol. Gen. Comp. Endocrinol. 176: 367-376.
• Lerner, D.T., Sheridan, M.A., and McCormick, S.D. 2012.  Estrogenic compounds decrease growth hormone receptor abundance and alter osmoregulation in Atlantic salmon.  Gen. Comp. Endocrinol. 179: 196-204.
• Hanson, A., Kittilson, J.D., McCormick, S.D., and Sheridan, M.A. 2012.  Effects of 17β-estradiol, 4-nonylphenol, and β-sitosterol on the growth hormone-insulin-like growth factor system and seawater adaptation of rainbow trout (Oncorhynchus mykiss).  Aquaculture, 362-363: 241-247.
• Reindl, K. and Sheridan, M.A. 2012.  Peripheral regulation of the growth hormone/insulin-like growth factor system in fish and other vertebrates.  Comp. Biochem. Physiol. A 163: 231-245.
• Bergan, H.E. and Sheridan, M.A. 2013.  Growth hormone-stimulated lipolysis in hepatocytes results from ERK and PKC-mediated activation and increased expression of hormone sensitive lipase. J. Mol. Endocrinol. 51:213-224.
• Ellens, E.R., Kittilson, J.D., Hall, J.A. Sower, S.A., and Sheridan, M.A. 2013.  Evolutionary origin and divergence of the growth hormone receptor family: Insight from studies on sea lamprey. Gen. Comp. Endocrinol. 192: 222-236.
• Walock., C., Kittilson, J.D., and Sheridan, M.A. 2013.  Isolation, characterization, and distribution of growth hormone receptor type 1 mRNA in rainbow trout (Oncorhynchus mykiss), and regulation of its expression by nutritional state.  Gene 553: 286-294.
• Hanson, A.M., Kittilson, J.D., Martin, L. Sheridan, M.A. 2014.  Environmental estrogens inhibit growth of rainbow trout (Oncorhynchus mykiss) by modulatingthe growth hormone-insulin-like growth factor system.  Gen. Comp. Endocrinol., 196: 130-138
• Caruso, M.A. and Sheridan, M.A. 2014. The expression of insulin and insulin receptor mRNAs is regulated by somatostatim in vivo and in vitro in rainbow trout (Oncorhynchus mykiss). Mol. Cell. Endocrinol., in press