Texas Tech University

Nutritional Sciences

Nutrigenomics, Inflammation and Obesity Research Lab (NIOR)

Nishan Sudheera Kalupahana, MBBS, Ph.D.


Book Chapters

  • Kalupahana NS, Moustaid-Moussa N, Voy BH, Kim JH, Bassett D, Bray MS, Lightfoot TJ. The Regulation of Physical Activity by Genetic Mechanisms: Is There a Drive to be Active? In: Genetic and Molecular Aspects of Sports Performance. Edited by Bouchard C, Hoffman E: Wiley-Blackwell; 2011: 283-293
  • Bray MS, Fulton JE, Kalupahana NS, Lightfoot TJ. Genetic Epidemiology, Physical Activity and Inactivity. In: Genetic and Molecular Aspects of Sport Performance. Edited by Bouchard C, Hoffman E: Wiley-Blackwell; 2011: 81-89
  • Siriwardhana N, Kalupahana NS and Moustaid-Moussa N. Health benefits of n-3 polyunsaturated fatty acids: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). In Handbook of Marine Medicinal Food: Applications and Implications (2nd Ed.) Edited by Se-Kwon Kim: Elsevier; 2012
  • Kalupahana NS, Jayalath T, Wang S and Moustaid-Moussa N. Regulation and metabolic effects of white adipose tissue SCD expression. In: Stearoyl Coenzyme-A Desaturase Genes in Lipid Metabolism. Edited by James M. Ntambi: Springer; 2013: 49-60
  • Kalupahana NS, Wang S, Rahman S and Moustaid-Moussa N. Function and regulation of macrophage SCD in metabolic disorders. In: Stearoyl Coenzyme-A Desaturase Genes in Lipid Metabolism. Edited by James M. Ntambi: Springer; 2013:61-71

Publications in peer-reviewed journals

  • Kalupahana NS, Weerasinghe VS, Dangahadeniya U, Senanayake N. Abnormal parameters of magnetically evoked motor evoked potentials in patients with cervical spondylotic myelopathy. Spine Journal 2008; 8(4):645-9
  • Wortman P, Miyazaki Y, Kalupahana NS, Kim S, Hansen-Petrik M, Saxton AM, Claycombe KJ, Voy BH, Whelan J and Moustaid-Moussa N. n3 and n6 polyunsaturated fatty acids differentially modulate prostaglandin E secretion but not markers of lipogenesis in adipocytes. Nutrition & Metabolism 2009; 6:5
  • Kalupahana NS, Claycombe K, Newman SJ, Stewart T, Siriwardhana N, Matthan N, Lichtenstein A and Moustaid-Moussa N. Eicosapentaenoic acid prevents and reverses insulin resistance in high-fat diet-induced obese mice via modulation of adipose tissue inflammation. Journal of Nutrition 2010; 140(11):1915-22
  • Kalupahana NS, Voy BH, Saxton A and Moustaid-Moussa N. Energy-restricted high-fat diets only partially improve markers of systemic and adipose tissue inflammation. Obesity (Silver Spring) 2011; 19(2):245-54
  • Kalupahana NS, Claycombe K and Moustaid-Moussa N. Omega-3 fatty acids alleviate adipose tissue inflammation and insulin resistance: mechanistic insights. Advances in Nutrition 2011; 2: 304-316
  • Kalupahana NS and Moustaid-Moussa N. Overview to Symposium “Systems Genetics in Nutrition and Obesity Research”. Journal of Nutrition 2011; 141(3):512-4
  • Kalupahana NS, Moustaid-Moussa N. Genetics, Physical Activity and Chronic Diseases: an Intricate Relationship. Sri Lanka Medical Journal, 2011; 20(1):1-15
  • Kalupahana NS and Moustaid-Moussa N. The adipose tissue renin-angiotensin system and metabolic disorders: a review of molecular mechanisms. Critical Reviews in Biochemistry and Molecular Biology, 2012;47(4):379-390
  • Kalupahana NS, Massiera F, Quignard-Boulange A, Ailhaud G, Voy BH, Wasserman DH and Moustaid-Moussa N. Overproduction of angiotensinogen from adipose tissue induces adipose tissue inflammation, glucose intolerance and insulin resistance. Obesity (Silver Spring), 2012 Jan;20(1):48-56.
  • Kalupahana NS, Moustaid-Moussa N and Claycombe K. Immunity as a link between obesity and insulin resistance. Molecular Aspects of Medicine, 2012 Feb;33(1):26-34.  
  • Kalupahana NS, Moustaid-Moussa N. The renin-angiotensin system: a link between obesity, inflammation and insulin resistance. Obesity Reviews, 2012 Feb;13(2):136-49.
  • Siriwardhana N, Kalupahana NS, Fletcher S, Xin W, Claycombe KJ, Quignard-Boulange A, Zhao L, Saxton AM, Moustaid-Moussa N. n-3 and n-6 polyunsaturated fatty acids differentially regulate adipose angiotensinogen and other inflammatory adipokines in part via NF-κB-dependent mechanisms. Journal of Nutritional Biochemistry, 2012 Apr 3.
  • Moustaid-Moussa N, Costello CA, Greer BP, Fitzhugh EC,  Spence ML, Muenchen RA and Kalupahana NS. Predictors of body mass index in female parents whose children participate in a competitive, creative, problem-solving program. Journal of Food and Nutrition Research, 2012; 56
  • Shi LZ, Kalupahana NS, Turnis ME, Neale G, Hock H, Vignali DA, Chi H. Inhibitory role of the transcription repressor Gfi1 in the generation of thymus-derived regulatory T cells. Proc Natl Acad Sci USA. 2013 Aug 5.
  • Fletcher SJ, Kalupahana NS, Bejnood M, Kim JH, Saxton AM, Wasserman D, De Taeye B, Voy BH, Quignard-Boulange A and Moustaid-Moussa N. Transgenic mice overexpressing renin exhibit glucose intolerance and diet-genotype interactions. Frontiers in Endocrinology, 2013 Jan 7;3:166
  • Siriwardhana N, Kalupahana NS, Cekanova M, Lemieux M, Greer B, Moustaid-Moussa N. Modulation of adipose tissue inflammation by bioactive food compounds. Journal of Nutritional Biochemistry, 2013 Apr;24(4):613-23
  • Carroll WX, Kalupahana NS, Booker SL, Siriwardhana N, Lemieux M, Saxton AM, Moustaid-Moussa N. Angiotensinogen gene silencing reduces markers of lipid accumulation and inflammation in cultured adipocytes. Front Endocrinol (Lausanne). 2013;4:10.
  • Somasundaram NP, Wijeyaratne CN, De Silva S, Siribaddana S, Illangasekera U, Rajaratnam H, Katulanda P, Bulugahapitiya U, Siyambalapitiya S, Antonypillai C, Sumanatilleke M, Katulanda G, Jayawardena P, Kalupahana NS et al. Diabetes Mellitus: Glucose Control. Sri Lanka Journal of Diabetes Endocrinology and Metabolism 2013; 3(1): 45-57
  • Abdel-Hamid T, Ankel F, Battle-Fisher M, Gibson B, Gonzalez-Parra G, Jalali M, Kaipainen K, Kalupahana NS et al. Public and health professionals' misconceptions about the dynamics of body weight gain/loss. System Dynamics Review 2014; 30(1-2): 58–74
  • Shi LZ, Zeng H, Kalupahana NS, Neale G and Chi H. The Gfi1-Foxo1 axis controls the fidelity of gene expression and developmental maturation of thymocytes. Submitted to Cell Reports, 2014
  • LeMieux MJ, Kalupahana NS, Scoggin S and Moustaid-Moussa N. Eicosapentaenoic acid induces adipocyte hypotrophy and reduces adipocyte inflammation in an adiposity-independent manner. Provisional acceptance, Journal of Nutrition, 2014

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Nutritional Sciences