Texas Tech University

Nutritional Sciences

Nutrigenomics, Inflammation and Obesity Research Lab (NIOR)

Naïma Moustaïd-Moussa, Ph.D., FTOS., Professor & Director, Obesity Research Cluster


  • Yvan-Charvet, L., Massiéra, F., Lamandé, N., Ailhaud, G., Teboul, M., Moustaid-Moussa, N., Gasc, J.M. and Annie Quignard-Boulangé.  Angiotensin type 2 receptor reverses obesity but not hypertension induced by overexpression of angiotensinogen in adipose tissue.  Endocrinology 150: 1421–1428, 2009. 
  • Wortman, P, Miyazaki, Y., Kalupahana, N., Kim, S., Hansen-Petrik, M., Saxton, A., Claycombe, K., Voy, BH., Whelan J and Moustaid-Moussa, N. PUFA modulate adipocyte prostaglandin secretion and fatty acid metabolism in 3T3-L1 adipocytes. Biomed Central Nutrition & Metabolism 2009, 6:5 doi:10.1186/1743-7075-6-5.Published: 21 January 2009.
  • Kalupahana, N.S. Moustaid-Moussa, N., Kim, J.H., Voy, B.H., Bassett, D. and Lightfoot, T.J. The Regulation of Physical Activity by Genetic Mechanisms: Is There a Drive to be Active? Invited book chapter for the Encycl. of Sports Medicine - "Genetic and MolecularAspects of Sport Performance". Eds. Bouchard/ Hoffman. 2010
  • Cho, KW., Lee, OH., Banz, WJ., Moustaid-Moussa, N., Shay, N., Kim, YC. Daidzein and the daidzein metabolite, equol, enhance adipocyte differentiation and PPARgamma transcriptional activity. J. Nutr. Biochem. Sep;21(9):841-7, 2010
  • Kalupahana, N.S., Claycombe, K.J., Newman, S.J., Stewart, T., Siriwardhana, N., Matthan, N., Lichtenstein, A.H., Moustaid-Moussa, N. Eicosapentaenoic Acid Prevents and Reverses Insulin Resistance in High-Fat Diet-Induced Obese Mice via Modulation of Adipose Tissue Inflammation. J. Nutr. 140: 1915–1922, 2010
  • Kalupahana, N., Voy, BH., Saxton, A. and Moustaid-Moussa, N. Differential effects of macronutrient composition and energy restriction on energy balance and adipose tissue gene expression. Obesity. Feb;19(2):245-54. Epub 2010 Sep 16. 2011
  • Kalupahana, N., and Moustaid-Moussa, N. Overview of “Systems Genetics in Nutrition and Obesity Research” Symposium. J Nutr; 141(3):512-514; 2011. Epub 2011 Jan 26; 2011
  • Benoit, R., Papin, J., Vacher, P., Raoux, M., Mulot, A., Dubois, M., Kerr-Conte, Voy, B., Pattou, F., Charpentier, G., Jonas, JC., Moustaid-Moussa, N. and Lang, J. ADCY 8 is central to GLP-1 signaling in pancreatic β-cells. Diabetologia. Feb;54(2):390-402; 2011
  • Hsueh, H.W., Zhou, Z., Whelan, J., Allen, K.D., Moustaid-Moussa, N., Kim, J., and Claycombe, K.J. Stearidonic and Eicosapentaenoic Acids Inhibit Interleukin-6 (IL-6) Expression in Mouse Adipose Stem Cells via Toll-like Receptor-2 (TLR2) Mediated Pathway. J Nutr. Jul;141(7):1260-1266; 2011.  Epub 2011 May 11; 2011
  • Kalupahana, N., Claycombe, K. and Moustaid-Moussa, N. (n-3) Fatty acids alleviate adipose tissue inflammation and insulin resistance: mechanistic insights. Adv. Nutr. Jul vol. 2: 304-316, 2011(http://advances.nutrition.org/content/2/4/304.full.pdf)
  • Kalupahana, N., Quignard-Boulange, Voy, BH., Saxton, A. and Moustaid-Moussa, N. Overexpression of angiotensinogen in adipose tissue increases adipose tissue inflammation and glucose intolerance. Obesity 20(1):48-56; 2012; Epub 2011 Oct 6.
  • Kalupahana, N., and Moustaid-Moussa, N. The Adipose tissue renin angiotensin: A link between obesity, inflammation and insulin resistance. Obes. Rev. Feb;13(2):136-49; 2012. Epub 2011 Oct 31.
  • Kalupahana, N.S., Moustaid-Moussa, N. and Claycombe, K.J. Immunity links obesity and insulin resistance.  Molecular Aspects of Medicine 33(1):26-34, 2012. Epub 2011 Oct 21
  • Siriwardhana, N., Kalupahana, N.S., Fletcher, S., Xin, W., Claycombe, K.J., Quignard-Boulange, A., Zhao, L., Saxton, A.M., Moustaid-Moussa, N.  n-3 and n-6 polyunsaturated fatty acids differentially regulate adipose angiotensinogen and other inflammatory adipokines via NF-KB-dependent mechanisms.  J. Nutr. Biochem. 23(12):1661-7; 2012
  • Siriwardhana, N., Kalupahana, N.S., Moustaid-Moussa, N. Health benefits of n-3 polyunsaturated fatty acids: eicosapentaenoic acid and docosahexaenoic acid.  Adv. Food. Nutr. Res. 65:211-22.  PMID: 22361189; 2012
  • Siriwardhana, S., Layman, R., Patel, S., Tage, B., Karwandyar, A., Matthew, C., Lampley, J., Rhody, C., Smith, E., Saxton, A.M., Moustaid-Moussa, N. and Wimalasena, J.  Role of inflammation in linking obesity to breast cancer.  J. Met. Syndrome; 1:1; 2012. DOI:10.4172/2167-0943.1000102 http://www.omicsgroup.org/journals/2167-0943/2167-0943-1-102.pdf
  • Maples, J., Fitzhugh, E.,  Costello, C.A., Bassett, D., Spence, M., Greer, B., Munchen, R., Moustaid-Moussa, N. Physical activity, screen time, and prevalence of overweight/obesity Among Adolescents in a creative, problem-solving program. Food Nut. Sci. 3: 568-578, 2012.  DOI:10.4236/fns.2012.34079. http://www.scirp.org/journal/PaperInformation.aspx?paperID=18506
  • Kalupahana, N.S., and Moustaid-Moussa, N.  The adipose tissue renin-angiotensin system and metabolic disorders: a review of molecular mechanisms.   . Crit Rev Biochem Mol Biol. Invited Review (peer-reviewed); 47(4):379-90; Jul-Aug 2012. PMID: 22720713
  • Moustaid-Moussa, N., Costello C,A., Greer, B.P., Spence, M., Fitzhugh, E., Muenchen, R., Kalupahana, N.S.  Predictors of BMI in female parents whose children participate in a competitive, creative, problem solving program. Food Nutr Res. 2012;56. doi: 10.3402/fnr.v56i0.17787. Epub 2012 Aug 16. PMID: 22912600
  • Zhou, Z., Neupane, M., Zhou, H.R., Wu, D., Chang, C-C., Moustaid-Moussa, N. and Claycombe, KJ. Leptin differentially regulate STAT3 activation in ob/ob mouse adipose mesenchymal stem cells. Nutrition & Metabolism (doi:10.1186/1743-7075-9-1092012);  9:109; 2012. http://www.nutritionandmetabolism.com/content/9/1/109
  • Fletcher SJ, Kalupahana NS, Bejnood M, Kim JH, Saxton A, Wasserman D, de Taeye B, Voy BH, Quignard-Boulange A., and Moustaid-Moussa N. Overexpression of renin in the liver impairs glucose tolerance and insulin secretion. Front. Endocrin. (Diabetes issue), 3(166):1-9; (Jan 7) 2013
  • Siriwardhana, N., Kalupahana, NS., Cekanova, M., Greer, B., LeMieux, M., Moustaid-Moussa, N., Modulation of adipose tissue inflammation by bioactive food compounds . J Nutr Biochem. 24(4):613-23, 2013
  • Xin, W., Kalupahana, N., Booker, S.Siriwardhana, N., Lemieux, M. and Moustaid-Moussa, N. Adipose angiotensinogen silencing decreases inflammation and adipogenesis. Front. Endocrin. (Diabetes issue); 4(10): 1-12, (Mar 11) 2013.
  • Dodson, MV., Boudina, S., Albrecht, E., Bucci, L., Fernyhough-Culver, M., Wei, S., Bergen, W., Amaral, AJ., Moustaid-Moussa, N., Poulos, S., and Hausman GK.  A long journey to effective obesity treatments: Is there light at the end of the tunnel? Exp. Biol. Med. In Press, 2013
  • Goktas Z, Moustaid-Moussa N, Shen CL, Boylan M, Mo H, Wang S.  Effects of bariatric surgery on adipokine-induced inflammation and insulin resistance. Front. Endocrinol. 4:69, 2013
  • LeMieux, M., AL-Jawadi, A., Wang, Shu and Moustaid-Moussa, N. MetabolicpProfiling in nutrition and metabolic disorders. Advances in Nutrition. In Press, 2013
  • Wang, S., Moustaid-Moussa; Chen, L., Mo, H., Shastri, A., Sun, R., Bapat, P., and Shen, C.L. Novel insights of dietary polyphenols and obesity. Invited Review, J. Nutr. Biochem. Accepted pending minor revisions, 2013


Nutritional Sciences