Henry J. Shine Endowed Lectures
Dr. Henry J. Shine, Paul Whitfield Horn Professor
This annual lecture series was endowed by students, colleagues and friends of Professor
Shine and supplemented by a grant from the Plum Foundation.
Dr. Shine was born in 1923 in London, England. He received the B. Sc. in chemistry
with first class honors from University College, London University in 1944, and his
Ph.D. in organic chemistry from Bedford College, London University in 1947. After
postdoctoral studies at Iowa State College and the California Institute of Technology,
he worked as a research chemist for United States Rubber Company. He joined the faculty
of the Department of Chemistry at Texas Tech University in 1954, where he soon became
one of the outstanding researchers at the University. In 1968, he was designated as
the first Paul Whitfield Horn Professor of Chemistry, an honor that recognized his
international research reputation. He was Chairman of the department during 1969-1975.
One of Professor Shine's research interests in physical organic chemistry has been
the use of heavy atom kinetic isotope effects to help answer difficult mechanistic
questions. His studies of the Claisen rearrangement in both aromatic and vinylic allyl
ethers played an important role in defining these reactions as concerted. His investigations
of the benzidine rearrangement likewise solved the longstanding question of mechanism.
His most recent research was focused on the chemistry of organic cation radicals,
concentrating on reactions that are induced by single-electron transfer (SET) to stable
cation radicals. This research has led to the discovery of the oxidative decomposition
of azoalkanes, which occurs when they react by SET with cation radicals, and leads
principally to carbocationic chemistry of these traditional sources of free radicals.
Related work has documented the chemistry of radicals formed by SET from Grignard
reagents and organomercurials to the thianthrene cation radical. His research in this
area has demonstrated the ways in which organosulfur cation radicals add to alkenes
and alkynes, and how the adducts lead to further interesting reactions.
Professor David W. C. MacMillan, Department of Chemistry, Princeton University
Public Lecture: Why is Chemistry and Catalysis Important to Society?
Technical Lecture: New Photoredox Reactions
Professor K. C. Nicolaou, Department of Chemistry, Rice University
Public Lecture: The Art and Science of Organic Synthesis and its Impact on Science
Technical Lecture: Total Synthesis of Natural and Designed Molecules of Biological
and Medical Importance
Professor M. Christina White, Department of Chemistry, University of Illinois
Public Lecture: Taming the Force of Oxidation
Technical Lecture: The Functionalization of C-H Bonds
Professor Melanie S. Sanford, Department of Chemistry, University of Michigan
"Tackling Problems in Sustainable Energy Using Transition Metal Catalysis"
Professor Stephen L. Buchwald, Camille Dreyfus Professor of Chemistry, Massachusetts Institute of Technology
Public Lecture: Palladium-Catalyzed Carbon-Nitrogen and Carbon-Carbon Bond-Formation
Reactions: Progress, Applications and Mechanistic Studies
Scientific Lecture: Flow Chemistry: Opportunities for the Development of New and Useful
Professor Robert M. Williams, Department of Chemistry, Colorado State University
"Quinine! A Story of Chemistry, History, Personalities and Ethics"
Professor Peter J. Stang, Department of Chemistry, University of Utah
"Chemical Publishing in the 21st Century: Perspectives of a JACS Editor"
Professor Aaron Ciechanover, Tumor and Vascular Biology Research Center, The Rappaport Faculty of Medicine and
Research Institute, Technion-Israel Institute of Technology
"Why Our Proteins Have to Die So We Shall Live"
Professor Iwao Ojima, Department of Chemistry, State University of New York at Stony Brook
"Tumor-Targeting Cancer Chemotherapy"
Professor Robert H. Grubbs, Division of Chemistry & Chemical Engineering, California Institute of Technology
"From Fundamental Research to Applications: The Olefin Metathesis Reaction"
Professor Jacqueline K. Barton, Division of Chemistry & Chemical Engineering, California Institute of Technology
"Travels Along the DNA Helix: A Different Perspective"
Professor Amos B. Smith, III, University of Pennsylvania
"Evolution of a Gram Scale Total Synthesis of (+)-Spongistatin 1: Challenges, Excitement,
Professor Dennis P. Curran, University of Pittsburgh
"An Introduction to Fluorous Synthesis: From Separating Mixtures to Making Mixtures"
Professor Peter B. Dervan, California Institute of Technology
"Regulation of Gene Expression by Synthetic DNA Binding Ligands"
Professor Clayton H. Heathcock, University of California, Berkeley
"Total Synthesis of Spongistatin, a Marine Natural Product with Unprecedented Cytotoxicity"