The development of a strain of Drosophila melanogaster that undergoes parthenogenesis leads to a generation of polyploid organisms. The bigger cell size of polyploid organisms can allow for research into cell mechanisms of Drosophila melanogaster, a model organism for development biology. Specifically, we are focused on the impact of nondisjunction on this research as it leads to birth defects in both humans and Drosophila melanogaster. However, the fecundity of this strain is quite low, and we have tried several methods to increase egg-laying of the unmated females. One of the methods that we used was to employ spermless males as a placebo to try to “trick” the females into producing more offspring. This led to a short-term increase, but unfortunately, the females died prematurely, leading to less overall offspring. In order to understand the cause of this mortality, we compared parthenogenetic vs. wild-type females when mated with spermless males, as well as when mated with wild-type males. To our surprise, we found that parthenogenetic females are less robust than wild-type females when raised alone but are more resistant to harm from spermless males. While this method to increase fertility is not suitable for our research, it does open new possibilities of investigation into exactly what protects the parthenogenetic females from the toxicity of the spermless males as we continue our research into the peculiar phenomenon of parthenogenesis in Drosophila melanogaster.