Dr. Joachim Weber
Title: Associate Professor
Education: Ph.D., Medical University of Lübeck, Germany, 1990; Postdoctoral, University of Rochester, NY, 1990-1995; Research Assistant Professor, University of Rochester, NY, 1995-2003
Research Area: Biochemistry
Office: Chemistry 413-D
Principal Research Interests
- ATP Synthase – The World’s Smallest Rotary Motor
- Mutational Analysis of Enzymatic Function
- Biophysical Chemistry
Dr. Weber’s current work focuses on the question how ATP binding and hydrolysis in the catalytic site drive subunit rotation, using a variety of approaches. The applied techniques range from molecular biology (site-directed mutagenesis) to biochemistry (protein chemistry, enzyme kinetics) to biophysical chemistry (fluorescence spectroscopy) and molecular modeling. Molecular dynamics simulations and torque measurements by single-molecule analysis are performed in collaboration with other laboratories. Noteworthy recent results of this research were (a) the identification of the catalytically-active nucleotide binding site, (b) the functional analysis of a unique hydrogen-bonding network between two subunits of the enzyme, and (c) further insight into the coupling mechanism between catalysis and rotation.
Research in Dr. Weber’s lab is supported by the NIH.