Lauren Gollahon, Ph.D.

Web Links:

https://sites.google.com/site/gollahonlab/

Research Interests

Dr. Gollahon’songoing research involves understanding aspects of cancer development,progression and metastasis, as well as testing candidate anticancer agents. Her two major research foci are: 1 The relationship between obesity, breast cancer and metastasis, mitochondrial dysfunction in breast cancer, and natural products in breast cancer treatments. 2 The relationship between obesity, dysfunctional liver metabolism and liver cancer development, and “Nutrition as Medicine” through ammonium supplementation of dietary proteins. She has active projects with colleagues in Nutritional Sciences, Animal Sciences, Veterinary Sciences. Her broad education background and understanding of Biological Systems, allows her to identify patterns that emerge from molecular and cellular pathways and integrate them into a contextual framework for potential application-based knowledge in the One Health arena. With rigorous student training, Dr. Gollahon’s graduate students have gone on to successfully occupy academic, medical professional and industrial positions.

Recent Publications (last 2 years)

Barr, B., Gollahon, L. (2024). Dietary Protein, and its Modification by Ammonium Hydrox-ide, Improves Longevity, Alters Mass Composition and Reduces Liver Lipid Droplet Size in a Sex-Based Dependent Manner in C3H/HeJ Mice. Nutrients, 16: Special Issue: Nutritional Value of Meat and Meat Products and Their Role in Human Health. In revision. 

Barr, B., Gollahon, L. (2024). Effects of Obesity on Sex, Aging and Cancer Development in a Longitudinal Study of High-Fat Diet Fed C3H/HeJ Mice. Obesities, In press. 

Garrison, E.C., Brown, A.M.V., Salaza,r M.M., Barr, B., Moustaid-Moussa, N., Gollahon, L.S. (2024). Microbiome Taxonomic and Functional Differences in C3H/HeJ Mice Fed a Long-Term High-Fat Diet with Beef Protein ± Ammonium Hydroxide Supplementation. Nutrients, 16(11):1613. https://doi.org/10.3390/nu16111613. 

Mubtasim, N., Moustaid-Moussa, N., Gollahon, L.S. (2022). The Complex Biology of the Metastasis-Promoting, Obesity-Induced Tumor Microenvironment in Breast Cancer. Int. J. Mol. Sci. 2022,  23, 2480. https://doi.org/10.3390/ijms23052480 

Olayiwola, Y., Gollahon, L. (2024). Natural Compounds and Breast Cancer: Chemo-Preventive and Therapeutic Capabilities of Chlorogenic Acid and Cinnamaldehyde. Pharmaceuticals, 17, 361. https://doi.org/10.3390/ph17030361 .  

Wolpert, N., Gollahon, L. (2024). A Novel Cell Culture Scratch Assay Platform Generates Reproducible Gaps for Quantitative Cell Movement-Based Studies. Adv Bioeng Biomed Sci Res, 7(2), 01-07. SSN: 2640-4133 | https://doi.org/10.1101/2024.03.11.584450  

Mubtasim, N., Barr, B., Boren, C., and Gollahon, L. (2024). Effects of Aging on Secreted Adipocytokines in Visceral Fat of Female C3H/HeJ Mice Consuming a Long-Term High-Fat Diet. Dietetics 3 (2), 191-213. https://doi.org/10.3390/dietetics3020016. 

Mubtasim, N., and Gollahon, L., (2023). The Effect of Adipocyte-Secreted Factors in Activating Focal Adhesion Kinase-Mediated Cell Signaling Pathway towards Metastasis in Breast Cancer Cells. International Journal of Molecular Sciences, 24(23), p.16605. https://doi.org/10.3390/ijms242316605. 

Mubtasim, N., and L. Gollahon. (2023). Characterizing 3T3-L1 MBX Adipocyte Cell Differentiation Maintained with Fatty Acids as an In Vitro Model to Study the Effects of Obesity. Life 13, 1712. https://doi.org/10.3390/life13081712. 

Munir, M.T., Halim, S.A., Santos, J.M., Khan, F., Khan, A., Rahman, M.M., Hussain, F., Al-Harrasi, A., Gollahon, L.S. and Rahman, S.M., (2023). A High Dose of Calcitriol Inhibits Glycolysis and M2 Macrophage Polarization in the Tumor Microenvironment by Repressing mTOR Activation: in vitro and Molecular Docking Studies. Cell Physiol Biochem, 57, pp.105-122.  

 Menikdiwela, K.R.; Guimarães, J.P.T.; Scoggin, S.; Gollahon, L.S. (2022). Moustaid-Moussa, N. Dietary pH Enhancement Improves Metabolic Outcomes in Diet-Induced Obese Male and Female Mice: Effects of Beef vs. Casein Proteins. Nutrients, 14, 2583. https://doi.org/10.3390/nu14132583 .  

Schuster, C., Wolpert, N., Moustaid-Moussa, N., Gollahon, L.S. (2022). Combinatorial Effects of the Natural Products Arctigenin, Chlorogenic Acid and Cinnamaldehyde Commit Oxidation Assassination on Breast Cancer Cells. Antioxidants, 11(3),591. https://doi.org/10.3390/antiox11030591 .