Nutritional Sciences

Nutrigenomics, Inflammation and Obesity Research Lab (NIOR)

Naïma Moustaïd-Moussa, Ph.D., FTOS., Professor & Director, Obesity Research Cluster

Recent Publications (2013-2018)

1. Fletcher SJ, Kalupahana NS, Bejnood M, Kim JH, Saxton A, Wasserman D, de Taeye B, Voy BH, Quignard-Boulange A., and Moustaid-Moussa N. Overexpression of renin in the liver impairs glucose tolerance and insulin secretion. Front. Endocrin. (Diabetes issue), 3(166):1-9; (Jan 7) 2013
2. Siriwardhana, N., Kalupahana, NS., Cekanova, M., Greer, B., LeMieux, M., Moustaid-Moussa, N., Modulation of adipose tissue inflammation by bioactive food compounds . J Nutr Biochem. 24(4):613-23, 2013
3. Xin, W., Kalupahana, N., Booker, S.Siriwardhana, N., Lemieux, M. and Moustaid-Moussa, N. Adipose angiotensinogen silencing decreases inflammation and adipogenesis. Front. Endocrin. (Diabetes issue); 4(10): 1-12, (Mar 11) 2013.
4. Dodson, MV., Boudina, S., Albrecht, E., Bucci, L., Fernyhough-Culver, M., Wei, S., Bergen, W., Amaral, AJ., Moustaid-Moussa, N., Poulos, S., and Hausman GK. A long journey to effective obesity treatments: Is there light at the end of the tunnel? Exp. Biol. Med. In Press, 2013
5. Goktas Z, Moustaid-Moussa N, Shen CL, Boylan M, Mo H, Wang S. Effects of bariatric surgery on adipokine-induced inflammation and insulin resistance. Front. Endocrinol. 4:69, 2013
6. Wang, S., Moustaid-Moussa; Chen, L., Mo, H., Shastri, A., Sun, R., Bapat, P., and Shen, C.L. Novel insights of dietary polyphenols and obesity. Invited Review, J. Nutr. Biochem. 2013
7. LeMieux, M., AL-Jawadi, A., Wang, Shu and Moustaid-Moussa, N. Metabolic Profiling in nutrition and metabolic disorders. Adv. in Nutrition. 4: 548–550, 2013
8. LeMieux, L; Al-Jawadi, A., Wang, S. and Moustaid-Moussa, N. Metabolic Profiling in Nutrition and Metabolic. Adv. Nutr. 4: 548–550, 2013
9. Wang, S., Su, R. Nie, S., Sun, M., Zhang, J., Wu, D., and Moustaid-Moussa, N. Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicals. J. Nutr. Biochem. Invited Review, In Press, 2013
10. Kalupahana, N.S., Jayalath, T., Wang, S. and Moustaid-Moussa, N. Regulation and metabolic effects of white adipose tissue SCD-1 expression; J.M. Ntambi (ed.) Stearoyl-CoA desaturase genes in lipid metabolism. Springer Science+Business Media, New York; DOI 10.1007/978-1-4614-7969-7_5; 2013
11. Kalupahana, N.S., Wang, S., Rahman, S.M. and Moustaid-Moussa, N. Function and regulation of macrophage SCD1 in metabolic disorders. J.M. Ntambi (ed.), Stearoyl-CoA Desaturase Genes in Lipid Metabolism. Springer Science+Business Media New York; DOI 10.1007/978-1-4614-7969-7_6; 2013
12. Wang, S., Miller, B., Matthan, N.R., Goktas, Z., Wu, D., Reed, D.B., Yin, X., Grammas, P., Moustaid-Moussa, N., Shen, C-L., Lichtenstein, A. Aortic Cholesterol Accumulation Correlates with Systemic Inflammation but not Hepatic and Gonadal Adipose Tissue Inflammation in LDL Receptor Null Mice. In press, Nutrition Research, 2013
13. Wang, S., Moustaid-Moussa, N.; Chen, L., Mo, H., Shastri, A., Sun, R., Bapat, P., and Shen, C.L. Novel insights of dietary polyphenols and obesity. Invited Review, J. Nutr. Biochem. 25 (1):1-18; 2014
14. Wang, S., Su, R. Nie, S., Sun, M., Zhang, J., Wu, D., and Moustaid-Moussa, N. Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicals. J. Nutr. Biochem. 25 (4): 363-76; 2014
15. LeMieux, L; Aljawadi, A., and Moustaid-Moussa, N. Nutrimetabolomics. Adv Nutr. 5(6):792-794; 2014
16. Crowe KM, Allison D and Bioactive Food Components Conference Speakers (Naima Moustaid-Moussa one of 21 collaborators). Evaluating bioactive food components in obesity and cancer prevention. Crit Rev Food Sci Nutr. 55(5):732-734; 2015
17. LeMieux, M., Kalupahana, N., Scoggin, S., and Moustaid-Moussa, N. EPA reduces adipocyte inflammation independent of adiposity. J. Nutr. 145(3):411-417, 2015.
18. Sams, V., Blackledge, C., Wijayatunga, N., Barlow, P., Mancini, M., Mancini, G., and Moustaid-Moussa, N. Effect of Bariatric Surgery on Systemic and Adipose Tissue Inflammation. Surgical Endoscopy; 30(8):3499-504, 2016
19. LeMieux M, Ramalingam L, Mynatt R, Kalupahana N, Kim J, Moustaid-Moussa N. Inactivation of Adipose Angiotensinogen Reduces Adipose Tissue Macrophages and Increases Adipose Cell Metabolic Activity. Obesity; 24(2):359-67; 2016
20. Rahman, S.M., Baquero, K.C., Choudhury, M., Janssen, R.C., de la Houssaye, B.A., Sun, M., Miyazaki-Anzai, S., Wang, S., Moustaid-Moussa, N., Miyazaki, M., Friedman, J.E. C/EBPβ in bone marrow is essential for diet induced inflammation, cholesterol balance, and atherosclerosis. Atherosclerosis. 2016. Jul; 250:172-9, 2016
21. Parkman, J.K., Mao, X., Dillon, X., Gudivada, A., Moustaid-Moussa, N., Saxton, A.M. and Kim, J.H. Genotype-dependent metabolic responses to semi-purified high-sucrose high-fat diets in the TALLYHO/Jng vs. C57BL/6 mouse during the development of obesity and type 2 diabetes. Exp. Clin. Endocrinol. Diabetes. 124(10):622-629, 2016
22. Pahlavani, M., Razafimanjato, F., Kalupahana, N., Ramalingam, L., Moussa, H., Scoggin, S. and Moustaid-Moussa, N. Eicosapentaenoic Acid Regulates Brown Adipose Tissue Metabolism in High Fat Fed Mice and in Clonal Brown Adipocytes. J. Nutr. Biochem., 39:101-109, 2017
23. Ramalingam, L., Menikdewella, K., LeMieux, L., Dufour, J., Kalupahana, N., and Moustaid-Moussa, N. The renin angiotensin system, oxidative stress and mitochondrial function in obesity and insulin resistance. Biochem. Biophys. Acta. Molecular basis for Disease. Biochim Biophys Acta. 1863(5):1106-1114, 2017
24. S. Liyanage, R.S. Dassanayake, A. Bouyanfif, E. Rajakaruna, L. Ramalingam, N. Moustaid-Moussa, N. Abidi. Optimization of cryostat temperature conditions for trans-reflectance mode FTIR microspectroscopic imaging of biological tissues. MethodsX, 4; 118-127, 2017.
25. Pahlavani, M., Kalupahana, N.S., Ramalingam, L., Moustaid-Moussa, N. Regulation and Functions of the Renin-Angiotensin System in White and Brown Adipose Tissue. Compr. Physiol. 7(4):1137-1150; 2017
26. Li S, Ning H, Ye Y, Wei W, Guo R, Song Q, Liu L, Liu Y, Na L, Niu Y, Chu X, Feng R, Moustaid-Moussa N, Li Y, Sun C. Increasing extracellular Ca2+ sensitizes TNF-alpha-induced vascular cell adhesion molecule-1 (VCAM-1) via a TRPC1/ERK1/2/NFκB-dependent pathway in human vascular endothelial cells. Biochim Biophys Acta. (Mol. Cell Res.) 2017 Jun 3;1864(10):1566-1577.
27. Pahlavani, M., Ramalho, T, Jayarathne, S., Koboziev, I., Ramalingam. L., Filgueiras, L.R., Moustaid-Moussa, N. Adipose tissue inflammation in insulin resistance: Review of mechanisms mediating anti-inflammatory effects of omega-3 polyunsaturated fatty acids. J. Inv. Med. 65(7):1021-1027; 2017
28. Allen, L., Ramalingam, L., Menikdiwela, M., Scoggin., Shen, C.L., Tomison, M.D., Kaur, G., Dufour, J., Chung, E., Kalupahana, N.S., Moustaid-Moussa, N. Effects of δ-Tocotrienol on Obesity-Related Adipocyte Hypertrophy, Inflammation, and Non-Alcoholic Fatty Liver Disease in High Fat Fed Mice. J. Nutr. Biochem. 48:128-137, 2017
29. Bouyanfif A, Liyanage S, Hewitt JE, Vanapalli SA, Moustaid-Moussa N, Hequet E, Abidi N. FTIR imaging detects diet and genotype-dependent chemical composition changes in wild type and mutant C. elegans strains. Analyst. 142(24):4727-4736; 2017
30. Jayarathne, S., Koboziev, I., Park, O.H., Oldewage-Theron, W., Shen, C.L., Moustaid-Moussa, N. Anti-Inflammatory and Anti-Obesity Properties of Food Bioactive Components: Effects on Adipose Tissue. Prev. Nutr. Food. 22(4), 251-262.
31. Aljawadi, A., Moussa, H., Ramalingam, L., Dharamawardhane, S., Gollahon, L., Gunaratne, P., Rahman R., and Moustaid-Moussa, N. Protective properties of n-3 fatty acids and implications in obesity-associated breast cancer. J. Nutr. Biochem. 53:1-8; 2017.
32. D'Costa, B.., Moustaid-Moussa, N., Gollahon, L.S. The Role of Exosomes in Breast Cancer: What Have We Learned in Ten Years? (Chapter 1) In: Triple-Negative Breast Cancer: Biomarkers, Emerging Therapeutic Strategies and Clinical Challenges. Editors: Marion Montgomery. Nova Science Publishers. Series: Cancer Etiology, Diagnosis and Treatments. ISBN: 978-1-53612-372-2; 2017
33. Wijayatunga N, Pahlavani M, Kottapalli R., Dawson J, Gunaratne P., Coarfa C., Rajapakshe K., Kalupahana N., Moustaid-Moussa N. Adipose Depot-Specific Differences in Transcriptome and MicroRNA Expression in High Fat Diet Induced Obese Mice. Oncotarget. 9:9246-9261, 2018 https://doi.org/10.18632/oncotarget.24226
34. Wijetunge, S., Kalupahana, NS., Ratnayake, RMCJ., Kotakadeniya, HMSRB., Rosairo, S., Albracht-Schulte, K., Ramalingam, L., and Moustaid-Moussa, N. Serum resistin and visceral adipocyte hypertrophy are associated with dysglycemia in South Asian women. J. Clin. Endo. Metab. Pending Review
35. Pahlavani M, Wijayatunga N., Kottapalli R., Dawson J, Gunaratne P., Coarfa C., Rajapakshe K., Kalupahana N., Moustaid-Moussa N. Transcriptome and miRNA profiling in brown adipose tissue of high fat fed mice supplemented with eicosapentaenoic acid. Biochem. Biophys. Acta Mol Cell Lipids. Pending Review

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