Rigaku's Synergy-S single crystal diffractometer is a top-of-the-line instrument equipped with both CuKα and MoKα radiation and paired with Rigaku's HyPix-6000HE detector. This instrument was installed in early 2019 and is capable of the molecular structure determination of a wide range of materials from cryogenic (100 K) to elevate (400 K) temperatures (Cryostream 700). These include, but are not limited to, organics and biological small-molecules, organometallic complexes, and inorganic compounds. Data can be collected for researchers, or trained users may collect their own data. Data integration is carried out using CrysAlisPro and structure solution and refinement with Olex2. Both programs can be downloaded for free.