Neurobiology of Nutrition Laboratory

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Publications

• Shah H, Kramer A, Mullins CA, Mattern M, Gannaban RB, Townsend RL, Campagna SR, Morrison CD, Berthoud HR, Shin AC. Reduction of plasma BCAAs following Roux-en-Y gastric bypass surgery is mediated by FGF21. Nutrients, 2023 15(7): 1713

• Shah H, Dehghani F, Ramezan M, Gannaban RB, Haque Z, Rahimi F, Abbasi S, Shin AC. Revisiting the role of vitamins and minerals in Alzheimer's disease. Antioxidants, 2023 12(2), 415

• Siddik MAB, Mullins CA, Kramer A, Shah H, Gannaban RB, Zabet-Moghaddam M, Huebinger RM, Hegde VK, MohanKumar SMJ, MohanKumar PS, Shin AC. Branched-chain amino acids are linked with Alzheimer's disease-related pathology and cognitive deficits. Cells, 2022 11(21): 3523
• Della Guardia L, Shin AC. PM2.5-induced adipose tissue dysfunction can trigger metabolic disturbances. Trends in Endocrinology & Metabolism, 2022 Sep 26, Online ahead of print

• Della Guardia L, Shin AC. The role of adipose tissue dysfunction in PM2.5-induced vascular pathology. American Journal of Physiology – Heart Circ Physiol, 2022 Jun 1; 322(6): H971-972

• Guardia LD, Shin AC. White and brown adipose tissue functionality is impaired by fine particulate matter (PM2.5) exposure. Journal of Molecular Medicine, 2022 Mar 14, Online ahead of print
• Clark KA, Shin AC, Sirivelu MP, MohanKumar RC, Maddineni SR, Ramachandran R, MohanKumar PS, MohanKumar SMJ. Evaluation of the central effects of systemic lentiviral-mediated leptin delivery in streptozotocin-induced diabetic rats. International Journal of Molecular Sciences, 2021 Epub ahead of print
• Akheruzzaman M, Hegde V, Siddik MAB, Feizy Z, Shin AC, Dhurandhar NV. E4orf1-induced reduction in endogenous insulin level is independent of pancreas endocrine function. International Journal of Obesity – Nature, 2021 Epub ahead of print
• Gannaban RB, NamKoong C, Ruiz HH, Choi HJ, Shin AC. Central regulation of branched-chain amino acids is mediated by AgRP neurons. Diabetes, 2021 Jan; 70(1): 62-75. Epub 2020 Oct 28.
• Galyean S, Sawant D, Shin AC. Immunometabolism, micronutrients, and bariatric surgery: The use of transcriptomics and microbiota-targeted therapies. Mediators of Inflammation, 2020 Nov 17; 2020:8862034
• Mullins CA, Gannaban RB, Khan MS, Shah H, Siddik MAB, Hegde V, Reddy PH, Shin AC. Neural underpinnings of obesity: the role of oxidative stress and inflammation in the brain. Antioxidants, 2020 Oct; 9(10): 1018
• Shin AC*, Balasubramanian P, Suryadevara P, Zyskowski J, Herdt TH , MohanKumar SM, MohanKumar PS. Metformin effectively restores the HPA axis function in diet-induced obese rats. International Journal of Obesity – Nature, 2020. *Corresponding author
• Galyean S, Sawant D, Shin AC. Personalized Nutrition for Management of Micronutrient Deficiency - Literature Review in Non-Bariatric Populations and Possible Utility in Bariatric Cohort. Obesity Surgery, 2020 Jun [Epub ahead of print]
• Akheruzzaman M, Hegde VK, Shin AC, Dhurandhar NV. Reducing endogenous insulin is linked with protection against hepatic steatosis in mice. Nutrition & Diabetes - Nature, 2020 
• Siddik MAB, Shin AC. Recent progress on branched-chain amino acids in obesity, diabetes, and beyond. Endocrinology and Metabolism (Invited Review), 2019 Sep; 34(3): 234-246
• Shah H, Shin AC. Meal patterns after bariatric surgery in mice and rats. Appetite (Special Issue on Bariatric Surgery – Invited Review), 2019 June 29 
• Patkar PP, Hao Z, Mumphrey MB, Townsend BL, Berthoud HR, Shin AC. Unlike calorie restriction, Roux-en-Y gastric bypass surgery does not increase hypothalamic AgRP and NPY in mice on a high-fat diet. International Journal of Obesity – Nature, 2019 Feb 
• Shin AC, MohanKumar SMJ, Balasubramanian P, Sirivelu MP, Linning K, Woolcock A, James M, MohanKumar PS. Responsiveness of HPA axis to leptin is impaired in diet-induced obese rats. Nutrition & Diabetes - Nature, 2019 Mar; 9(1): 10
• Liu P, Ji Y, Yuen T, Redina-Reudy E, DeMambro V, Lu P, Dhawan S, Abu-Amer W, Shnayder V, Zhou B, Shin AC, Robinson S, Yu Y, Zhou Y, Zhu L, Reagan M, New M, Epstein S, Guo E, Iqbal J, Molina H, Thangeswaran P, Haider S, Davies T, Buettner C, Bian Z, Sun L, Rosen C, Brown A, Zhang X, Yang F, Oberlin DJ, Latif R, Kumar T, Klinken JV, Gupta A, Li J, Izadmehr S, Zaidi M. Blocking FSH induces thermogenic adipose tissue and reduces body fat. Nature, 2017 Jun; 546(7656): 107-112
• Shin AC, Filatova N, Lindtner C, Chi T, Degann S, Oberlin DJ, Buettner C. Insulin receptor signaling in POMC, but not AgRP, neurons controls adipose tissue insulin action. Diabetes, 2017 Jun; 66(6): 1560-1571
• Fischer K, Ruiz HH, Jhun K, Finan B, Oberlin DJ, van der Heide V, Kalinovich AV, Petrovic N, Wolf Y, Clemmensen C, Shin AC, Divanovic S, Brombacher F, Glasmacher E, Keipert S, Jastroch M, Nagler J, Schramm K, Medrikova D, Collden G, Woods SC, Herzig S, Homann D, Jung S, Nedergaard J, Cannon B, Tschöp MH, Müller TD, Buettner C. Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis. Nature Medicine, 2017 May; 23(5): 623-630
• Shin AC. Are BCAAs mere biomarkers of diabetes? Diabetes Res Open J, 2017 Jan; 3(1): e4-e8
• Jiang C, Lin WJ, Sadahiro M, Shin AC, Buettner C, Salton SR. Embryonic ablation of neuronal VGF increases energy expenditure and reduces body weight. Neuropeptides, 2017 Aug; 64: 75-83
• Ruiz HH, Chi T, Shin AC, Lindtner C, HsiehW, Ehrlich M, Gandy S, Buettner C. Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer's Disease is associated with impaired hypothalamic insulin signaling and elevated BCAA levels. Alzheimer's and Dementia, 2016 Aug; 12(8): 851-61
• Kang S, Dahl R, Hsieh W, Shin AC, Zsebo KM, Buettner C, Hajjar RJ, Lebeche D. Small Molecular Allosteric Activator of the Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) Attenuates Diabetes and Metabolic Disorders. J Biol Chem, 2016 Mar 4; 291(10): 5185-98
• Sadahiro M, Erickson C, Lin WJ, Shin AC, Razzoli M, Jiang C, Fargali S, Gurney A, Kelley KA, Buettner C, Bartolomucci A, Salton SR. Role of VGF-derived carboxy-terminal peptides in energy balance and reproduction: analysis of 'humanized' knockin mice expressing full length or truncated VGF. Endocrinology, 2015 May; 156(5): 1724-38
• Shin AC, Fasshauer M, Filatova N, Grundell LA, Zielinski E, Zhou J, Scherer T, Lindtner C, White PJ, Lapworth AL, Ilkayeva O, Knippschild U, Wolf AM, Scheja L, Grove KL, Smith RD, Qian WJ, Lynch CJ, Newgard CB, Buettner C. Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism. Cell Metabolism, 2014 Nov; 20(5): 898-909
• Shin AC, Berthoud HR. Obesity surgery: happy with less or eternally hungry? Trends Endocrinol Metab, 2013 Feb; 24(2): 101-8
• Shin AC, Zheng H, Berthoud HR. Longitudinal assessment of food intake, fecal energy loss and energy expenditure after Roux-en-Y gastric bypass surgery in high-fat fed obese rats. Obesity Surgery, 2013 April; 23(4): 531-40
• Kasturi BS, MohanKumar SM, Sirivelu MP, Shin AC, MohanKumar PS. Chronic oestradiol-17β exposure suppresses hypothalamic norepinephrine release and the steroid-induced luteinizing hormone surge: Role of nitration of tyrosine hydroxylase. Brain Research, 2013 Feb 1; 1493: 90-8
• Fargali S, Scherer T, Shin AC, Sadahiro M, Buettner C, Salton SR. Germline ablation of VGF increases lipolysis in white adipose tissue. Journal of Endocrinology, 2012 Nov; 215(2): 313-22
• Berthoud HR, Zheng H, Shin AC. Food reward in the obese and after weight loss induced by calorie restriction or bariatric surgery. Annals of New York Academy of Sciences, 2012 Aug; 1264(1): 36-48
• Shin AC, Zheng H, Berthoud HR. Vagal innervation of hepatic portal vein and liver is not necessary for Roux-en-Y gastric bypass surgery-induced hypophagia, weight loss, and hypermetabolism. Annals of Surgery, 2012 Feb; 255(2): 294-301
• Shin AC, Berthoud HR. Food reward functions as affected by obesity and bariatric surgery. International Journal of Obesity – Nature, 2011 Sep; 35(Suppl 3): S40-4
• Shin AC, Townsend RL, Patterson LM, Berthoud HR. 'Liking' and 'wanting' of sweet and oily food stimuli as affected by high-fat diet-induced obesity, weight loss, leptin, and genetic predisposition. American Journal of Physiology: Reg Integ Comp Physiol, 2011 Nov; 301(5): R1267-80
• Berthoud HR, Lenard NR, Shin AC. Food reward, hyperphagia, and obesity. American Journal of Physiology: Reg Integ Comp Physiol, 2011 Jun; 300(6) R1266-77
• Berthoud HR, Shin AC, Zheng H. Obesity surgery and gut-brain communication. Physiology and Behavior, 2011 Nov; 105(1): 106-19
• MohanKumar SM, Kasturi BS, Shin AC, Balasubramanian P, Gilbreath E, Subramaniam M, MohanKumar PS. Chronic estradiol exposure induces oxidative stress in the hypothalamus to decrease hypothalamic dopamine and cause hyperprolactinemia. American Journal of Physiology: Reg Integ Comp Physiol, 2011 Mar; 300(3): R693-9
• Shin AC, Zheng H, Pistell PJ, Berthoud HR. Roux-en-Y gastric bypass surgery changes food reward in rats. International Journal of Obesity – Nature, 2011 May; 35(5): 642-51
• Shin AC, Pistell PJ, Phifer CB, Berthoud HR. Reversible suppression of food reward behavior by chronic μ-opioid receptor antagonism in the nucleus accumbens. Neuroscience, 2010 Oct; 170(2): 580-8
• Zheng H, Townsend RL, Shin AC, Patterson LM, Phifer CB, Berthoud HR. High-fat intake induced by μ-opioid activation of the nucleus accumbens is inhibited by Y1R-blockade and MC3/4R-stimulation. Brain Research, 2010 Sep; 1350: 131-8
• Shin AC, Zheng H, Townsend RL, Sigalet DL, Berthoud HR. Meal-induced hormone responses in a rat model of Roux-en-Y gastric bypass surgery. Endocrinology, 2010 Apr; 151(4): 1588-97
• Shin AC, MohanKumar SM, Sirivelu MP, Claycombe KJ, Haywood JR, Fink GD, MohanKumar PS. Chronic exposure to a high fat diet affects stress axis function differentially in diet-induced obese and diet-resistant rats. International Journal of Obesity – Nature, 2010 Jul; 34(7): 1218-26
• Zheng H, Shin AC, Lenard NR, Townsend RL, Patterson LM, Sigalet DL, Berthoud HR. Meal patterns, satiety, and food choice in a rat model of Roux-en-Y gastric bypass surgery. American Journal of Physiology: Reg Integ Comp Physiol, 2009 Nov; 297(5): R1273-82
• Shin AC, Zheng H, Berthoud HR. An expanded view of energy homeostasis: neural integration of metabolic, cognitive, and emotional drives to eat. Physiology and Behavior, 2009 Jul; 97(5): 572-80
• Zheng H, Lenard N, Shin AC, Berthoud HR. Appetite control and energy balance regulation in the modern world: external stimuli overwhelm internal repletion signals in a reward-driven brain. International Journal of Obesity – Nature, 2009 Jun; 33 Suppl 2: S8-13
• Sirivelu MP, Shin AC, Perez G, MohanKumar PS, MohanKumar SM. Effect of L-DOPA on IL-1β-induced suppression of luteinizing hormone secretion in intact female rats. Human Reproduction, 2009 Mar; 24(3): 718-25
• Sirivelu MP, Burnett B, Shin AC, Kim C, MohanKumar PS, MohanKumar SM. Interaction between GABA and norepinephrine in IL-1_β-induced suppression of lutenizing hormone surge. Brain Research, 2009 Jan; 1248: 107-14
• Clark KA, Shin AC, Sirivelu MP, MohanKumar SM, MohanKumar PS. Systemic administration of leptin decreases plasma corticosterone levels: role of hypothalamic norepinephrine. Brain Research, 2008 Feb; 1195: 89-95
• MohanKumar SM, King A, Shin AC, Sirivelu MP, MohanKumar PS, Fink GD. Developmental programming of cardiovascular disorders: Focus on hypertension. Review of Endocrine and Metabolic Disorders, 2007 Jun; 8(2):115-25
• Pasarica M, Shin AC, Yu M, Ou Yang HM, Rathod M, Jen KL, MohanKumar SM, MohanKumar PS, and Dhurandhar NV. Human Adenovirus Ad-36 induces adiposity, increases insulin sensitivity, and alters hypothalamic monoamines and stress axis in rat. Obesity, 2006 Nov; 14(11):1905-13

Other Publications 

• Shin AC, Zheng H, Sigalet DL, Berthoud HR. Gut-brain communication and food reward: altered 'liking' and taste-guided ingestion in a rat model of Roux-en-Y gastric bypass surgery. Press Book, Society for Neuroscience Meeting, Chicago, IL, 2009
• Shin AC, MohanKumar SM, Sirivelu MP, Zhao H, Haywood JR, Fink GD, MohanKumar PS. Hypothalamo-pituitary-adrenal dysfunction in diet-induced obese rats: possible role for defective leptin signaling. Press Book, Society for Neuroscience Meeting, Atlanta, Georgia, 2006
• Shin AC, MohanKumar SM, Zhao H, Haywood JR, MohanKumar PS. Development of diet-induced obesity: Possible role for IL-1ß. Press Book, Society for Neuroscience Meeting, Washington D.C., 2005