Texas Tech University

Neurobiology of Nutrition Laboratory

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Research Interests

Dr. Shin's lab is interested in how the brain controls metabolism and nutrient partitioning as well as the long-term regulation of body weight and appetite. The main research project aims to understand the role of insulin action in the brain in regulating branched-chain amino acid (BCAA) metabolism and how this central control can contribute to glucose homeostasis by using molecular, pharmacological, transgenic, surgical, and integrative physiological approaches.

Other ongoing research projects:

  • Association between Type 2 diabetes and Alzheimer's disease
  • Effects of Roux-en-Y gastric bypass (RYGB) surgery on appetite, hedonics, and reward control and the underlying mechanisms
  • Understanding how nicotine affects blood glucose

Current Funding

  • NIH R01 AG071560-01A1
    • Serotonin-modulated mitochondrial dysfunction in dementia, depression and diabetes, Feb 2022 – Jan 2027

       

      (PI: Arubala Reddy; Co-I: Andrew C. Shin)
  • NIH R21 AG069140-01
    • BCAAs as a novel biomarker and treatment for Alzheimer's disease, Sep 2020 – Aug 2022
  • Scientific & Technological Research Council of Turkey
    • The effects of central and systemic irisin on glucose homeostasis in diet-induced obese mice, Nov 2020 – Oct 2022
  • Wylie Briscoe Fund, College of Human Sciences, TTU
    • Serum metabolomics in women with Alzheimer's disease, Dec 2021 – Dec 2022

      (PI: Andrew C. Shin)

 

Nutritional Sciences