Texas Tech University

Dr. Haibo Ge

Haibo

Title: Associate Professor

Education: Ph.D., University of Kansas, 2006
Postdoctoral Study, The Scripps Research Institute

Research Area: Organic Chemistry

Office: Chemistry 223-D

Phone: 806-834-4411

Email: haibo.ge@ttu.edu

Website: Ge Group

Principal Research Interests

  • Organometallic Chemistry
  • C-H Bond Functionalization
  • Medicinal Chemistry

Research in our group focuses on the development of metal-catalyzed carbon-carbon and carbon-heteroatom bond formation through C-H activation and total synthesis and structure-activity relationship studies of biologically active natural products. Current research programs in our laboratory include: 1) transition metal-catalyzed C-H functionalization: investigation of novel transformations on aromatic and aliphatic substrates; 2) transition metal-catalyzed cascade reactions; 3) synthesis and structure-activity relationship studies of selective aldehyde dehydrogenase inhibitors.


Representative Publications

  • Li, B.-J.; Lawrence, B.; Li, G.-G.; Ge, H.-B. Ligand‐controlled direct γ‐c−h arylation of aldehydes. Angew. Chem. Int. Ed. 2020, DOI: 10.1002/anie.201913126.
  • Li, B.-J.; Ge, H.-B. Highly selective electrochemical hydrogenation of alkynes: rapid construction of mechanochromic materials. Sci. Adv. 2019, DOI: 10.1126/sciadv.aaw2774.
  • Li, B.-J.; Seth. K.; Niu, B.; Pan, L.; Yang, H.-W.; Ge, H.-B. Transient ligand enabled ortho-arylation of five-membered heterocyclic carbonyl compounds: Facile build-up of mechanochromic materials. Angew. Chem. Int. Ed. 2018, 57, 3401-3405.
  • Liu, Y.-B.; Ge, H.-B. Site-selective C-H arylation of primary aliphatic amines enabled by a catalytic transient directing group. Nat. Chem. 2017, 9, 26-32.
  • Yang, K.; Li, Q.; Liu, Y.-B.;Li, G.-G.; Ge, H.-B. Catalytic C−H arylation of aliphatic aldehydes enabled by a transient ligand. J. Am. Chem. Soc. 2016, 138, 12775-12778.
  • Wu, X.-S.; Zhao, Y.; Ge, H.-B. Direct aerobic carbonylation of C(sp2)−H and C(sp3)−H bonds through Ni/Cu synergistic catalysis with DMF as the carbonyl source. J. Am. Chem. Soc. 2015, 137, 4924-4927.
  • Wu, X.-S.; Yang, K.; Zhao, Y.; Sun, H.; Li, G.-G.; Ge, H.-B. Cobalt-catalyzed site-selective intra- and intermolecular dehydrogenative amination of unactivated sp3 carbons. Nat. Commun. 2015, 6, 6462-6468.
  • Wu, X.-S.; Zhao, Y.; Ge, H.-B. Nickel-catalyzed site-selective alkylation of unactivated C(sp3)−H bonds. J. Am. Chem. Soc. 2014, 136, 1789-1792.
  • Wu, X.-S.; Zhao, Y.; Zhang, G.-W.; Ge, H.-B. Copper-catalyzed site-selective intramolecular amidation of unactivated C(sp3)−H bonds. Angew. Chem. Int. Ed. 2014, 53, 3706-3710.
  • Zhang, G.-W.; Zhao, Y.; Ge, H.-B. Copper-catalyzed aerobic dehydrogenative cyclization of N,N-dimethylhydrazones via sp3 C−H bond functionalization. Angew. Chem. Int. Ed. 2013, 52, 2559-2563.
  • Zhang, G.-W.; Miao, J.-M.; Zhao, Y.; Ge, H.-B. Copper-catalyzed aerobic dehydrogenative cyclization of N-methyl-N-phenylhydrazones: Synthesis of cinnolines. Angew. Chem. Int. Ed. 2012, 51, 8318-8321.

Department of Chemistry & Biochemistry